Activating Compound | Comment | Organism | Structure |
---|---|---|---|
AMP | activation | Fasciola hepatica | |
AMP | one of three most potent activators | Fasciola hepatica | |
cAMP-dependent protein kinase | activation by phosphorylation | Fasciola hepatica | |
cAMP-dependent protein kinase | kinetics, one of three most potent activators | Fasciola hepatica | |
D-fructose 1,6-bisphosphate | activation | Fasciola hepatica | |
D-fructose 2,6-bisphosphate | activation of native and phosphorylated PFK, one of three most potent activators | Fasciola hepatica | |
D-Glucose 1,6-bisphosphate | activation | Fasciola hepatica |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Aldolase | - |
Fasciola hepatica | |
Aldolase | - |
Ovis aries | |
ATP | - |
Fasciola hepatica | |
ATP | - |
Ovis aries | |
citrate | strong inhibition; weak inhibition | Fasciola hepatica | |
citrate | strong inhibition; weak inhibition | Ovis aries | |
phosphatase | dephosphorylation inactivates | Fasciola hepatica | |
phosphatase | dephosphorylation inactivates | Ovis aries |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetic study | Ovis aries | |
additional information | - |
additional information | kinetic study | Fasciola hepatica | |
additional information | - |
additional information | allosteric kinetics at alkaline pH-values | Fasciola hepatica | |
additional information | - |
additional information | kinetic properties of phosphorylated enzyme | Ovis aries | |
additional information | - |
additional information | kinetic properties of phosphorylated enzyme | Fasciola hepatica |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
K+ | - |
Fasciola hepatica | |
Mg2+ | required for activity | Ovis aries | |
Mg2+ | required for activity | Fasciola hepatica |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Fasciola hepatica | - |
- |
- |
Ovis aries | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
side-chain modification | - |
Fasciola hepatica |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Ovis aries | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-fructose 6-phosphate | - |
Ovis aries | ADP + D-fructose 1,6-bisphosphate | - |
? | |
ATP + D-fructose 6-phosphate | - |
Fasciola hepatica | ADP + D-fructose 1,6-bisphosphate | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
native enzyme | Fasciola hepatica |
7.6 | - |
phosphorylated enzyme | Fasciola hepatica |