Protein Variants | Comment | Organism |
---|---|---|
G434D | kinase-defective dominant-negative mutant , impairs hepatocyte growth factor- and v-Src-induced cell scatter and migration, without affecting the loss of intercellular adhesions, impairs hepatocyre growth factor-induced cell spreading, lamellipodia formation, membrane ruffling, and focal adhesions remodeling and impairs hepatocyte growth factor-induced Rac activation and membrane targeting | Canis lupus familiaris |
additional information | downregulation of diacylglycerol kinase alpha by siRNA impairs hepatocyte growth factor- and v-Src-induced cell scatter and migration, without affecting the loss of intercellular adhesions, impairs hepatocyre growth factor-induced cell spreading, lamellipodia formation, membrane ruffling, and focal adhesions remodeling and impairs hepatocyte growth factor-induced Rac activation and membrane targeting | Canis lupus familiaris |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
R59949 | specific inhibition of diacylglycerol kinase alpha. Inhibition impairs impairs hepatocyte growth factor- and v-Src-induced cell scatter and migration, without affecting the loss of intercellular adhesions, impairs hepatocyre growth factor-induced cell spreading, lamellipodia formation, membrane ruffling, and focal adhesions remodeling and impairs hepatocyte growth factor-induced Rac activation and membrane targeting | Canis lupus familiaris |
Organism | UniProt | Comment | Textmining |
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Canis lupus familiaris | - |
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Source Tissue | Comment | Organism | Textmining |
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MDCK cell | - |
Canis lupus familiaris | - |