Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q7TS91 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hypothalamus | expressed at high abundance in both hypothalami and clonal hypothalamic neurons. In response to re-feeding, isoform PFKFB3 mRNA levels are increased by 10fold in mouse hypothalami | Mus musculus | - |
neuron | expressed at high abundance in both hypothalami and clonal hypothalamic neurons | Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
inducible 6-phosphofructo-2-kinase | - |
Mus musculus |
iPFK2 | - |
Mus musculus |
PFKFB3 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | upon re-feeding, isoform PFKFB3 mRNA levels are increased by 10fold in mouse hypothalami | up |
General Information | Comment | Organism |
---|---|---|
physiological function | knockdown of isoform PFKFB3/iPFK2 in N-43/5 neurons causes a decrease in rates of glycolysis, which is accompanied by increased AMP-activated protein kinase phosphorylation, increased agouti-related protein mRNA levels and decreased cocaine-amphetamine-related transcript mRNA levels. Overexpression of PFKFB3/iPFK2 in N-43/5 neurons causes an increase in glycolysis, which is accompanied by decreased AMP-activated protein kinase phosphorylation and decreased agouti-related protein mRNA levels and increased cocaine-amphetamine-related transcript mRNA levels | Mus musculus |