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Literature summary for 2.7.1.105 extracted from
- 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) is up-regulated in high-grade astrocytomas (2008), J. Neurooncol., 86, 257-264.
Application
| Application | Comment | Organism |
|---|---|---|
| pharmacology | role of PFKFB3 protein in tumorigenesis, expression studies in human astrocytic gliomas of different malignancy grades | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O60825 | - |
- |
| Homo sapiens | P16118 | - |
- |
| Homo sapiens | Q16875 | - |
- |
| Homo sapiens | Q16877 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| gel filtration | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| astrocytoma cell | 40 human astrocytic gliomas and 20 non-neoplastic brain tissue specimens, different malignity grades, expression analysis in | Homo sapiens | - |
| astrocytoma cell | low and high malignancy grades according to histological criteria, expression analysis in | Homo sapiens | - |
| glioblastoma multiforme cell | expression analysis in | Homo sapiens | - |
| pilocytic astrocytoma cell | expression analysis in | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
expression analysis in different tumor specimens with high and low malignity grade, RT-PCR and Western blot | Homo sapiens |
| additional information | - |
proto-oncogenic character of the PFK-2/FBPase-2 of the PFKFB3 gene assumed to play a critical role in tumorigenesis, expression analyzed by RT-PCR and Western blot, expression up-regulated in astrocytomas with high malignity grade | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | expression analysis in different tumor specimens with high and low malignity grades, high expression of the PFKFB3 protein as an explanation for high glycolytic flux and lactate production in these tumors | Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Pfk-2 | - |
Homo sapiens |
| PFKFB3 | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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