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Literature summary for 2.7.1.105 extracted from

  • Telang, S.; Yalcin, A.; Clem, A.L.; Bucala, R.; Lane, A.N.; Eaton, J.W.; Chesney, J.
    Ras transformation requires metabolic control by 6-phosphofructo-2-kinase (2006), Oncogene, 25, 7225-7234.
    View publication on PubMed

Application

Application Comment Organism
medicine the pharmacologic inhibition of this enzyme may effect the survival and growth of neoplastic cells Mus musculus
medicine the pharmacologic inhibition of this enzyme may effect the survival and growth of neoplastic cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the expression of the inducible PFK2/FBPase is selectively necessary for the control of glycolytic flux in cells transformed with ras ?
-
?
additional information Homo sapiens the expression of the inducible PFK2/FBPase is selectively necessary for the control of glycolytic flux in cells transformed with ras ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bronchial epithelial cell ras-transformed Homo sapiens
-
lung fibroblast ras-transformed Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the expression of the inducible PFK2/FBPase is selectively necessary for the control of glycolytic flux in cells transformed with ras Mus musculus ?
-
?
additional information the expression of the inducible PFK2/FBPase is selectively necessary for the control of glycolytic flux in cells transformed with ras Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
Mus musculus
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase
-
Homo sapiens
PFK-2/FBPase
-
Mus musculus
PFK-2/FBPase
-
Homo sapiens