Protein Variants | Comment | Organism |
---|---|---|
additional information | enzyme contains four tryptophan residues: Trp15, Trp64, Trp299 and Trp320, mutant enzymes contain either no Trp or a single Trp at each location, the other Trp residues having been converted to Phe, mutations do not cause large change in protein conformation and function, Trp299 and Trp320 in mutant enzymes quenched by iodide to a small extent can indicate an altered conformation, Trp64 is not accessible | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
guanidine | inactivation, unfolding | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | comparison of Km of wild-type and mutant enzyme | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate | bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46 | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
testis | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-D-fructose 6-phosphate | - |
Rattus norvegicus | ADP + beta-D-fructose 2,6-bisphosphate | - |
r | |
additional information | also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) | Rattus norvegicus | ? | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | guanidine-inhibition of wild-type and mutant enzymes | Rattus norvegicus |