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Literature summary for 2.7.1.105 extracted from

  • Li, L.; Lange, A.J.; Pilkis, S.J.
    Isolation of a cDNA for chicken liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase [published erratum appears in Biochem Biophys Res Commun 1999 Jun 16;259(3):711] (1993), Biochem. Biophys. Res. Commun., 190, 397-405.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Gallus gallus
expression in Escherichia coli Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
Mg2+ MgATP Gallus gallus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02 0.03 beta-D-fructose 6-phosphate pH 7.5, 30°C, in presence of phosphate Gallus gallus
0.02 0.03 beta-D-fructose 6-phosphate pH 7.5, 30°C, in presence of phosphate Rattus norvegicus
0.1
-
 ATP
-
 Rattus norvegicus
0.1
-
 beta-D-fructose 6-phosphate pH 7.5, 30°C Gallus gallus
0.1
-
 beta-D-fructose 6-phosphate pH 7.5, 30°C Rattus norvegicus
0.1
-
 ATP pH 7.5, 30°C, in absence of phosphate Gallus gallus
0.12 0.36 ATP pH 7.5, 30°C, kinetic study Gallus gallus
0.12 0.36 ATP pH 7.5, 30°C, kinetic study Rattus norvegicus
1 1.1 beta-D-fructose 6-phosphate pH 7.5, 30°C, in absence of phosphate Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ inhibition Gallus gallus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 2,6-bisphosphate bifunctional protein: 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, reverse reaction catalysed by fructose 2,6-bisphosphatase: 3.1.3.46 Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Gallus gallus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-D-fructose 6-phosphate
-
 Gallus gallus ADP + beta-D-fructose 2,6-bisphosphate
-
 r
ATP + beta-D-fructose 6-phosphate
-
 Rattus norvegicus ADP + beta-D-fructose 2,6-bisphosphate
-
 r
additional information also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) Gallus gallus ?
-
 ?
additional information also catalyses the degradation of fructose 2,6-bisphosphate (EC 3.1.3.46) Rattus norvegicus ?
-
 ?