Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + D-glucose | - |
Mus musculus | ADP + D-glucose 6-phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ATP:D-glucose 6-phosphotransferase | - |
Mus musculus |
LGK | - |
Mus musculus |
liver glucokinase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | a small heterodimer partner decreasesliver glucokinase gene expression by inhibiting the transcriptional activity of liver X receptoralpha and peroxisome proliferator-activated receptor-gamma by directly interacting with their common heterodimer partner RXRalpha | down |
Mus musculus | liver X receptoralpha increases liver glucokinase expression in primary hepatocytes, expression of liver glucokinase is induced mainly regulated by insulin through sterol regulatory element-binding protein-1c as a mediator, peroxisome proliferator-activated receptor-gamma also stimulates liver glucokinase expression through a peroxisome proliferator-responsive element | up |