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Literature summary for 2.7.1.1 extracted from

  • Kim, T.H.; Kim, H.; Park, J.M.; Im, S.S.; Bae, J.S.; Kim, M.Y.; Yoon, H.G.; Cha, J.Y.; Kim, K.S.; Ahn, Y.H.
    Interrelationship between liver X receptor alpha, sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor gamma, and small heterodimer partner in the transcriptional regulation of glucokinase gene expression in liver (2009), J. Biol. Chem., 284, 15071-15083.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Mus musculus
-
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-glucose
-
Mus musculus ADP + D-glucose 6-phosphate
-
?

Synonyms

Synonyms Comment Organism
ATP:D-glucose 6-phosphotransferase
-
Mus musculus
LGK
-
Mus musculus
liver glucokinase
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Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Mus musculus

Expression

Organism Comment Expression
Mus musculus a small heterodimer partner decreasesliver glucokinase gene expression by inhibiting the transcriptional activity of liver X receptoralpha and peroxisome proliferator-activated receptor-gamma by directly interacting with their common heterodimer partner RXRalpha down
Mus musculus liver X receptoralpha increases liver glucokinase expression in primary hepatocytes, expression of liver glucokinase is induced mainly regulated by insulin through sterol regulatory element-binding protein-1c as a mediator, peroxisome proliferator-activated receptor-gamma also stimulates liver glucokinase expression through a peroxisome proliferator-responsive element up