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Literature summary for 2.7.1.1 extracted from

  • Zhang, L.; Li, H.; Zhu, Q.; Liu, J.; Chen, L.; Leng, Y.; Jiang, H.; Liu, H.
    Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase (2009), Bioorg. Med. Chem., 17, 7301-7312.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
1-(1-(4-chlorophenyl)cyclohexyl)-3-(thiazol-2-yl)urea
-
Homo sapiens
2-amino-4-fluoro-5-((1-methyl-1H-imidazol-2-yl)thio)-N-(thiazol-2-yl)benzamide
-
Homo sapiens
2-amino-4-fluoro-5-(1,3,4-thiadiazol-2-ylsulfanyl)-N-(3-trifluoromethyl-phenyl)-benzamide 1.14fold activation at 0.01 mM Homo sapiens
2-amino-4-fluoro-5-(1-methyl-1H-imidazol-2-ylsulfanyl)-N-(3-trifluoromethyl-phenyl)-benzamide 1.47fold activation at 0.01 mM Homo sapiens
2-amino-4-fluoro-5-(4-methyl-thiazol-2-ylsulfanyl)-N-(3-trifluoromethyl-phenyl)-benzamide 0.89fold activation at 0.01 mM Homo sapiens
2-amino-4-fluoro-5-(thiazol-2-ylsulfanyl)-N-(3-trifluoromethyl-phenyl)-benzamide 1.15fold activation at 0.01 mM Homo sapiens
2-amino-4-fluoro-N-(3-fluoro-phenyl)-5-(1,3,4-thiadiazol-2-ylsulfanyl)-benzamide 1.36fold activation at 0.01 mM Homo sapiens
2-amino-4-fluoro-N-(3-fluoro-phenyl)-5-(1-methyl-1Himidazol-2-ylsulfanyl)-benzamide 2.04fold activation at 0.01 mM Homo sapiens
2-amino-4-fluoro-N-(3-fluoro-phenyl)-5-(pyridin-2-ylsulfanyl)-benzamide 1.1fold activation at 0.01 mM Homo sapiens
2-amino-4-fluoro-N-(3-fluoro-phenyl)-5-(thiazol-2-ylsulfanyl)-benzamide 1.25fold activation at 0.01 mM Homo sapiens
2-amino-4-fluoro-N-(3-methoxy-phenyl)-5-(1-methyl-1H-imidazol-2-ylsulfanyl)-benzamide 1.15fold activation at 0.01 mM Homo sapiens
2-amino-4-fluoro-N-(4-methoxy-phenyl)-5-(1-methyl-1H-imidazol-2-ylsulfanyl)-benzamide 2.01fold activation at 0.01 mM Homo sapiens
2-amino-5-(benzoxazol-2-ylsulfanyl)-4-fluoro-N-(3-fluoro-phenyl)-benzamide 0.83fold activation at 0.01 mM Homo sapiens
2-amino-N-(3,4-dimethoxy-phenyl)-4-fluoro-5-(1-methyl-1H-imidazol-2-ylsulfanyl)-benzamide 1.32fold activation at 0.01 mM Homo sapiens
2-amino-N-(3-amino-phenyl)-4-fluoro-5-(1,3,4-thiadiazol-2-ylsulfanyl)-benzamide 1.22fold activation at 0.01 mM Homo sapiens
2-amino-N-(3-amino-phenyl)-4-fluoro-5-(1-methyl-1H-imidazol-2-ylsulfanyl)-benzamide 2.09fold activation at 0.01 mM Homo sapiens
2-amino-N-(3-amino-phenyl)-4-fluoro-5-(4-methylthiazol-2-ylsulfanyl)-benzamide 1.1fold activation at 0.01 mM Homo sapiens
2-amino-N-(3-amino-phenyl)-4-fluoro-5-(pyridin-2-ylsulfanyl)-benzamide 1.12fold activation at 0.01 mM Homo sapiens
2-amino-N-(3-amino-phenyl)-4-fluoro-5-(thiazol-2-ylsulfanyl)-benzamide 1.21fold activation at 0.01 mM Homo sapiens
2-amino-N-(3-amino-phenyl)-5-(4,6-dimethyl-pyrimidin-2-ylsulfanyl)-4-fluoro-benzamide 1.09fold activation at 0.01 mM Homo sapiens
2-amino-N-(3-aminomethyl-phenyl)-4-fluoro-5-(1-methyl-1H-imidazol-2-ylsulfanyl)-benzamide 1.01fold activation at 0.01 mM Homo sapiens
2-amino-N-(3-cyano-phenyl)-4-fluoro-5-(1,3,4-thiadiazol-2-ylsulfanyl)-benzamide 1.2fold activation at 0.01 mM Homo sapiens
2-amino-N-(3-cyano-phenyl)-4-fluoro-5-(1-methyl-1Himidazol-2-ylsulfanyl)-benzamide 1.95fold activation at 0.01 mM Homo sapiens
2-amino-N-(3-cyano-phenyl)-4-fluoro-5-(4-methylthiazol-2-ylsulfanyl)-benzamide 0.99fold activation at 0.01 mM Homo sapiens
2-amino-N-(3-cyano-phenyl)-4-fluoro-5-(thiazol-2-ylsulfanyl)-benzamide 1.2fold activation at 0.01 mM Homo sapiens
2-amino-N-(3-cyano-phenyl)-5-(4,6-dimethyl-pyrimidin-2-ylsulfanyl)-4-fluoro-benzamide 1.01fold activation at 0.01 mM Homo sapiens
2-cyclopentyl-1-(4-(methylsulfonyl)phenyl)-N-(thiazol-2-yl)ethanesulfonamide
-
Homo sapiens
2-[4-(2,4-difluoro-phenyl)-piperazin-1-yl]-N-(3,4-dimethoxy-phenyl)-acetamide 1.01fold activation at 0.01 mM Homo sapiens
2-[4-(2-fluoro-phenyl)-piperazin-1-yl]-N-(3-trifluoromethyl-phenyl)-acetamide 1.06fold activation at 0.01 mM Homo sapiens
3-(5-chlorothiazol-2-yl)-1-(4-(methylsulfonyl)phenyl)-1-(thiophen-3-ylmethyl)urea
-
Homo sapiens
3-amino-N-[2-amino-4-fluoro-5-(1-methyl-1H-imidazol-2-ylsulfanyl)-phenyl]-benzamide 1.16fold activation at 0.01 mM Homo sapiens
LY-2121260
-
Homo sapiens
N,N'-bis-(2-methoxy-phenyl)-isophthalamide 1.02fold activation at 0.01 mM Homo sapiens
N,N'-bis-(3-methoxy-phenyl)-isophthalamide 0.81fold activation at 0.01 mM Homo sapiens
N,N'-bis-(4-methoxy-phenyl)-isophthalamide 0.89fold activation at 0.01 mM Homo sapiens
N-(3-amino-phenyl)-2-[4-(2-fluoro-phenyl)-piperazin-1-yl]-acetamide 1.08fold activation at 0.01 mM Homo sapiens
N-(3-cyano-phenyl)-2-[4-(2-fluoro-phenyl)-piperazin-1-yl]-acetamide 0.96fold activation at 0.01 mM Homo sapiens
N-(3-fluoro-phenyl)-2-[4-(2-fluoro-phenyl)-piperazin-1-yl]-acetamide 1.01fold activation at 0.01 mM Homo sapiens
RO-0281675
-
Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-glucose
-
Homo sapiens ADP + D-glucose 6-phosphate
-
?

Synonyms

Synonyms Comment Organism
glucokinase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens