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Literature summary for 2.7.1.1 extracted from

  • Miller, S.; Ross-Inta, C.; Giulivi, C.
    Kinetic and proteomic analyses of S-nitrosoglutathione-treated hexokinase A: consequences for cancer energy metabolism (2007), Amino Acids, 32, 593-602.
    View publication on PubMed
Search for more literature for 2.7.1.1

Inhibitors

Inhibitors Comment Organism Structure
S-nitrosoglutathione hexokinase is particularly susceptible to protein structure modifications when exposed to even low concentrations of S-nitrosoglutathione. Biologically relevant [S-nitrosoglutathione]/[hexokinase] causes a significant decrease in Vmax with glucose (but not with fructose), along with oxidation of 5 Met and nitration of 4 Tyr. Preincubation of hexokinase with glucose abrogates the effect of S-nitrosoglutathione whereas fructose is ineffective Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.3
-
 D-glucose S-nitrosoglutathione treated enzyme Saccharomyces cerevisiae
0.47
-
 D-glucose
-
 Saccharomyces cerevisiae
2.9
-
 D-fructose
-
 Saccharomyces cerevisiae
2.9
-
 D-fructose S-nitrosoglutathione treated enzyme Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P04806
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-fructose
-
 Saccharomyces cerevisiae ADP + D-fructose 6-phosphate
-
 ?
ATP + D-glucose
-
 Saccharomyces cerevisiae ADP + D-glucose 6-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
hexokinase A
-
 Saccharomyces cerevisiae
HXK A
-
 Saccharomyces cerevisiae

pI Value

Organism Comment pI Value Maximum pI Value
Saccharomyces cerevisiae
-
-
 5.3