Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.1.1 extracted from

  • Cesar, M.deC.; Wilson, J.E.
    Functional characteristics of hexokinase bound to the type A and type B sites of bovine brain mitochondria (2002), Arch. Biochem. Biophys., 397, 106-112.
    View publication on PubMed
Search for more literature for 2.7.1.1

Inhibitors

Inhibitors Comment Organism Structure
1,5-Anhydro-D-glucitol 6-phosphate hexokinase bound at type A and type B sites of brain mitochondria is relatively insensitive, hexokinase bound at type B sites, after removal of enzyme of type A sites, shows increased sensitivity Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion bound at type A sites and type B sites of brain mitochondria, ratio of type A:type B is 40:60, enzyme bound at type A sites is releaved by glucose 6-phosphate, but not that of type B sites Bos taurus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glucose + ATP Bos taurus cerebral glycolytic metabolism, mechanisms for regulation of mitochondrial hexokinase activity may depend on the ratio of type A:type B sites D-glucose 6-phosphate + ADP
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glucose + ATP hexokinase bound at type A and B sites of brain mitochondria selectively uses intramitochondrial ATP as substrate, but hexokinase bound at type B sites, after removal of enzyme of type A sites, shows no such selectivity Bos taurus ADP + D-glucose 6-phosphate
-
 ?
D-glucose + ATP cerebral glycolytic metabolism, mechanisms for regulation of mitochondrial hexokinase activity may depend on the ratio of type A:type B sites Bos taurus D-glucose 6-phosphate + ADP
-
 ?

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Bos taurus