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Literature summary for 2.7.1.1 extracted from
- The purification and properties of human hexokinase (1981), Biochem. Soc. Trans., 9, 245.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| D-glucose 6-phosphate | inhibitor blocks the action of hexokinase by effecting a conformational change in the structure of enzyme | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | enzyme has the ability to associate with cellular organelles, this association indicates a conformational equilibrium which is strikingly influenced by glucose 6-phosphate | Homo sapiens | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 110000 | - |
1 * 110000, heart hexokinase, monomer with a tendency to form aggregates, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucose + ATP | Homo sapiens | initial enzyme of glycolysis | D-glucose 6-phosphate + ADP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| from blood: 175000fold, from heart: 1700fold | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | - |
Homo sapiens | - |
| heart | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 37 | - |
hexokinase from blood, at 25°C | Homo sapiens |
| 58 | - |
hexokinase from heart, at 25°C, pH 7.2 | Homo sapiens |
| 150 | - |
hexokinase from heart, at 25°C, pH 8 | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glucose + ATP | - |
Homo sapiens | ADP + D-glucose 6-phosphate | - |
? | |
| D-glucose + ATP | initial enzyme of glycolysis | Homo sapiens | D-glucose 6-phosphate + ADP | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 110000, heart hexokinase, monomer with a tendency to form aggregates, SDS-PAGE | Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
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