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Literature summary for 2.6.1.89 extracted from

  • Melançon, C.E. 3rd.; Hong, L.; White, J.A.; Liu, Y.N.; Liu, H.W.
    Characterization of TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase from the D-mycaminose biosynthetic pathway of Streptomyces fradiae: in vitro activity and substrate specificity studies (2007), Biochemistry, 46, 577-590.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Streptomyces fradiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate Streptomyces fradiae the enzyme is involved in biosynthesis of D-mycaminose dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate
-
r

Organism

Organism UniProt Comment Textmining
Streptomyces fradiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Streptomyces fradiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CDP-3-dehydro-6-deoxy-alpha-D-glucose + L-glutamate
-
Streptomyces fradiae CDP-3-amino-3,6-dideoxy-alpha-D-glucose + 2-oxoglutarate
-
?
dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate the enzyme is involved in biosynthesis of D-mycaminose Streptomyces fradiae dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate
-
r
dTDP-3-dehydro-2,6-dideoxy-alpha-D-glucose + L-glutamate
-
Streptomyces fradiae TDP-3-amino-2,3,6-trideoxy-alpha-D-glucose + 2-oxoglutarate
-
?
dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate
-
Streptomyces fradiae dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate no formation of TDP-4-oxo-6-deoxy-alpha-D-glucose r
additional information no activity with TDP-4-keto-6-deoxy-D-glucose Streptomyces fradiae ?
-
?

Synonyms

Synonyms Comment Organism
TDP-3-dehydro-6-deoxy-D-glucose 3-aminotransferase
-
Streptomyces fradiae
TDP-3-keto-6-deoxy-D-glucose 3-aminotransferase
-
Streptomyces fradiae
TylB
-
Streptomyces fradiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Streptomyces fradiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay Streptomyces fradiae

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate a pyridoxal-phosphate protein Streptomyces fradiae