Literature summary for 2.6.1.82 extracted from

Jorge, J.M.; Leggewie, C.; Wendisch, V.F.
A new metabolic route for the production of gamma-aminobutyric acid by Corynebacterium glutamicum from glucose (2016), Amino Acids, 48, 2519-253.

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Application

Application	Comment	Organism
synthesis	a route for the production of GABA via putrescine in Corynebacterium glutamicum. A putrescine-producing recombinant Corynebacterium glutamicum strain is converted into a GABA producing strain by heterologous expression of putrescine transaminase PatA and gamma-aminobutyraldehyde dehydrogenase PatD genes from Escherichia coli. The resultant strain produces 5.3 g per l of GABA. GABA production is improved further by adjusting the concentration of nitrogen in the culture medium, by avoiding the formation of the by-product N-acetylputrescine and by deletion of the genes for GABA catabolism and GABA re-uptake. GABA accumulation by this strain is increased by 5% to 8.0 g per l, and the volumetric productivity is increased to 0.31 g per l and h	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P42588	-	-

Synonyms

Synonyms	Comment	Organism
PatA	-	Escherichia coli

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Release 2023.1 (January 2023)