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Literature summary for 2.6.1.7 extracted from
- Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesis (2008), Curr. Opin. Struct. Biol., 18, 748-755.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| E64G | the naturally occurring mutation in rat KAT I results in dramatically impaired kynurenic acid synthesis and in an associated spontaneously hypertensive phenotype | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-kynurenine + 2-oxobutyrate | - |
Homo sapiens | kynurenic acid + 2-aminobutanoate + H2O | - |
? |  |
| L-kynurenine + 2-oxobutyrate | - |
Rattus norvegicus | kynurenic acid + 2-aminobutanoate + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| KAT II | identical with alpha-aminoadipate aminotransferase | Homo sapiens |
| KAT II | identical with alpha-aminoadipate aminotransferase | Rattus norvegicus |
| type II kynurenine aminotransferase | - |
Homo sapiens |
| type II kynurenine aminotransferase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Homo sapiens | |
| pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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