Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cysteine | - |
Homo sapiens | |
Indole-3-pyruvate | 5 mM, complete inhibition | Homo sapiens | |
Tris | Tris buffer pH 7.5, low activity, pH 8.0, no activity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.7 | - |
L-cysteine | pH 7.5, 45°C | Homo sapiens | |
0.8 | - |
phenylpyruvate | pH 7.5, 45°C | Homo sapiens | |
1 | - |
2-oxoisocaproate | pH 7.5, 45°C | Homo sapiens | |
1.2 | - |
L-tryptophan | pH 7.5, 45°C | Homo sapiens | |
1.5 | - |
glyoxylate | pH 7.5, 45°C | Homo sapiens | |
1.7 | - |
L-phenylalanine | pH 7.5, 45°C | Homo sapiens | |
2.5 | - |
Mercaptopyruvate | pH 7.5, 45°C | Homo sapiens | |
2.8 | - |
L-glutamine | pH 7.5, 45°C | Homo sapiens | |
3 | - |
2-oxobutanoate | pH 7.5, 45°C | Homo sapiens | |
3.2 | - |
L-tyrosine | pH 7.5, 45°C | Homo sapiens | |
4.2 | - |
oxaloacetate | pH 7.5, 45°C | Homo sapiens | |
4.7 | - |
L-kynurenine | pH 7.5, 45°C | Homo sapiens | |
5.4 | - |
L-histidine | pH 7.5, 45°C | Homo sapiens | |
6.4 | - |
L-methionine | pH 7.5, 45°C | Homo sapiens | |
7.6 | - |
L-leucine | pH 7.5, 45°C | Homo sapiens | |
12.1 | - |
pyruvate | pH 7.5, 45°C | Homo sapiens | |
21.3 | - |
2-aminobutanoate | pH 7.5, 45°C | Homo sapiens | |
23.1 | - |
L-asparagine | pH 7.5, 45°C | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
46000 | - |
x * 46000, SDS-PAGE, x * 47875, calculated | Homo sapiens |
47875 | - |
x * 46000, SDS-PAGE, x * 47875, calculated | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
expression in Sf9 system | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-asparagine + 2-oxobutanoate | - |
Homo sapiens | 2-oxosuccinamic acid + 2-aminobutanoate | - |
? | |
L-cysteine + 2-oxobutanoate | - |
Homo sapiens | 2-aminobutanoate + 3-mercapto-2-oxopropanoate | - |
? | |
L-glutamine + 2-oxobutanoate | - |
Homo sapiens | 2-oxoglutarate + 2-aminobutanoate | - |
? | |
L-histidine + 2-oxobutanoate | - |
Homo sapiens | 3-(1H-imidazol-4-yl)-2-oxopropanoate + 2-aminobutanoate | - |
? | |
L-kynurenine + 2-oxobutanoate | - |
Homo sapiens | 4-(2-aminophenyl)-2,4-dioxobutanoate + 2-aminobutanoate | - |
? | |
L-kynurenine + 2-oxoisocaproate | - |
Homo sapiens | 4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine | - |
? | |
L-kynurenine + glyoxylate | - |
Homo sapiens | 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine | - |
? | |
L-kynurenine + mercaptopyruvate | - |
Homo sapiens | 4-(2-aminophenyl)-2,4-dioxobutanoate + L-cysteine | - |
? | |
L-kynurenine + oxaloacetate | - |
Homo sapiens | 4-(2-aminophenyl)-2,4-dioxobutanoate + 2-aminosuccinate | - |
? | |
L-kynurenine + phenylpyruvate | - |
Homo sapiens | 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine | - |
? | |
L-kynurenine + pyruvate | - |
Homo sapiens | 4-(2-aminophenyl)2,4-dioxobutanoate + L-alanine | - |
? | |
L-leucine + 2-oxobutanoate | - |
Homo sapiens | 2-oxoisocaproate + 2-aminobutanoate | - |
? | |
L-methionine + 2-oxobutanoate | - |
Homo sapiens | 4-methylsulfanyl-2-oxobutanoate + 2-aminobutanoate | - |
? | |
L-phenylalanine + 2-oxobutanoate | - |
Homo sapiens | phenylpyruvate + 2-aminobutanoate | - |
? | |
L-tryptophan + 2-oxobutanoate | - |
Homo sapiens | 3-indole-2-oxopropanoate + 2-aminobutanoate | - |
? | |
L-tyrosine + 2-oxobutanoate | - |
Homo sapiens | 3-(4-hydroxyphenyl)-2-oxopropanoate + 2-aminobutanoate | - |
? | |
additional information | very bad substrate: L-glycine, L-alanine, L-arginine, L-serine, L-lysine, no substrate: l-threonine, L-isoleucine, L-aspartate, L-glutamate, L-valine, L-aminoadipate | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 46000, SDS-PAGE, x * 47875, calculated | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
KAT-I | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
9.6 | - |
L-cysteine | pH 7.5, 45°C | Homo sapiens | |
14.4 | - |
L-asparagine | pH 7.5, 45°C | Homo sapiens | |
29 | - |
pyruvate | pH 7.5, 45°C | Homo sapiens | |
38.3 | - |
2-aminobutanoate | pH 7.5, 45°C | Homo sapiens | |
43.1 | - |
L-tryptophan | pH 7.5, 45°C | Homo sapiens | |
91 | - |
L-phenylalanine | pH 7.5, 45°C | Homo sapiens | |
91 | - |
L-tyrosine | pH 7.5, 45°C | Homo sapiens | |
110 | - |
phenylpyruvate | pH 7.5, 45°C | Homo sapiens | |
143 | - |
oxaloacetate | pH 7.5, 45°C | Homo sapiens | |
143 | - |
L-histidine | pH 7.5, 45°C | Homo sapiens | |
201 | - |
L-kynurenine | pH 7.5, 45°C | Homo sapiens | |
215 | - |
L-methionine | pH 7.5, 45°C | Homo sapiens | |
234 | - |
2-oxobutanoate | pH 7.5, 45°C | Homo sapiens | |
234 | - |
Mercaptopyruvate | pH 7.5, 45°C | Homo sapiens | |
263 | - |
glyoxylate | pH 7.5, 45°C | Homo sapiens | |
296 | - |
2-oxoisocaproate | pH 7.5, 45°C | Homo sapiens | |
339 | - |
L-leucine | pH 7.5, 45°C | Homo sapiens | |
440 | - |
L-glutamine | pH 7.5, 45°C | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7.5 | 9 | - |
Homo sapiens |