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Literature summary for 2.6.1.7 extracted from

  • Baran, H.; Cairns, N.; Lubec, B.; Lubec, G.
    Increased kynurenic acid levels and decreased brain kynurenine aminotransferase I in patients with Down syndrome (1996), Life Sci., 58, 1891-1899.
    View publication on PubMed
Search for more literature for 2.6.1.7

Inhibitors

Inhibitors Comment Organism Structure
glutamine 0.08 mM; inhibition of KAT I Homo sapiens
L-phenylalanine inhibition of KAT I Homo sapiens
L-tryptophan inhibition of KAT I Homo sapiens
additional information KAT II is not inhibited by glutamine, tryptophan and phenylalanine Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 kynurenine aminotransferase I and II, i.e. KAT I and KAT II, in elderly Down syndrome patients
-

Source Tissue

Source Tissue Comment Organism Textmining
brain frontal and temporal cortex Homo sapiens
-
frontal lobe
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-kynurenine + 2-oxoglutarate KAT I shows far higher activity with 2-oxoisohexanoate than with 2-oxoglutarate Homo sapiens kynurenic acid + L-glutamate + H2O
-
 ?
L-kynurenine + 2-oxoisohexanoate KAT I shows far higher activity with 2-oxoisohexanoate than with 2-oxoglutarate Homo sapiens kynurenic acid + 2-aminoisohexanoate + H2O
-
 ?
L-kynurenine + pyruvate KAT I shows far higher activity with 2-oxoisohexanoate and pyruvate than with 2-oxoglutarate Homo sapiens kynurenic acid + L-alanine + H2O
-
 ?

Synonyms

Synonyms Comment Organism
KAT I
-
 Homo sapiens
KAT II
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 8 KAT II from brain Homo sapiens
9.6 10 KAT I from brain, sharp optimum Homo sapiens