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Literature summary for 2.6.1.7 extracted from

  • De Antoni, A.; Costa, C.; Allegri, G.
    Studies on the kynurenine adminotransferase activity in rat liver and kidney (1976), Hoppe-Seyler's Z. Physiol. Chem., 357, 1707-1712.
    View publication on PubMed
Search for more literature for 2.6.1.7

Inhibitors

Inhibitors Comment Organism Structure
L-kynurenine substrate inhibition above 6 mM Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5
-
 L-3-hydroxykynurenine pH 7.2, 37°C, kidney mitochondria Rattus norvegicus
2.5
-
 L-kynurenine pH 7.2, 37°C, kidney supernatant Rattus norvegicus
3
-
 L-kynurenine pH 7.2, 37°C, liver supernatant Rattus norvegicus
3.4
-
 L-kynurenine pH 7.2, 37°C, kidney mitochondria Rattus norvegicus
5
-
 L-kynurenine pH 7.2, 37°C, liver mitochondria Rattus norvegicus
5
-
 L-3-hydroxykynurenine pH 7.2, 37°C, liver supernatant Rattus norvegicus
5.3
-
 L-3-hydroxykynurenine pH 7.2, 37°C, kidney supernatant Rattus norvegicus
6.3
-
 L-3-hydroxykynurenine pH 7.2, 37°C, liver mitochondria Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion 80% of liver total activity Rattus norvegicus 5739
-
mitochondrion 40% of kidney total activity Rattus norvegicus 5739
-
additional information subcellular distribution Rattus norvegicus
-
-
soluble 60% of kidney total activity Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-3-hydroxykynurenine + 2-oxoglutarate
-
 Rattus norvegicus xanthurenic acid + L-glutamate
-
 ?
L-kynurenine + 2-oxoglutarate
-
 Rattus norvegicus kynurenic acid + L-glutamate + H2O
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Rattus norvegicus