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Literature summary for 2.6.1.64 extracted from

  • Bridges, C.C.; Krasnikov, B.F.; Joshee, L.; Pinto, J.T.; Hallen, A.; Li, J.; Zalups, R.K.; Cooper, A.J.
    New insights into the metabolism of organomercury compounds: mercury-containing cysteine S-conjugates are substrates of human glutamine transaminase K and potent inactivators of cystathionine gamma-lyase (2012), Arch. Biochem. Biophys., 517, 20-29.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CH3-S-Hg-homocysteine 50% inhibition at 0.5 mM Homo sapiens
CH3Hg-S-Cys substrate and reversible inhibitor, 50% inhibition at 0.5 mM Homo sapiens
Cys-S-Hg-S-Cys substrate and reversible inhibitor, 37% inhibition at 0.5 mM Homo sapiens
homocysteine-S-Hg-S-homocysteine 67% inhibition at 1 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CH3Hg-S-Cys + phenylpyruvate
-
Homo sapiens ? + L-phenylalanine
-
?
Cys-S-Hg-S-Cys + phenylpyruvate
-
Homo sapiens ? + L-phenylalanine
-
?
L-cystathionine + phenylpyruvate
-
Homo sapiens S-(2-oxo-2-carboxyethyl)homocysteine + L-phenylalanine
-
?
L-cysteine + phenylpyruvate
-
Homo sapiens 3-mercapto-2-oxopropanoate + L-phenylalanine
-
?
L-methionine + phenylpyruvate
-
Homo sapiens 4-methylsulfanyl-2-oxobutanoate + L-phenylalanine
-
?