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Literature summary for 2.6.1.62 extracted from

  • Stoner, G.L.; Eisenberg, M.A.
    Biosynthesis of 7,8-diaminopelargonic acid from 7-keto-8-aminopelargonic acid and S-adenosyl-L-methionine. The kinetics of the reaction (1975), J. Biol. Chem., 250, 4037-4043.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
7-amino-8-oxononanoate 2 mM Escherichia coli
7-Keto-8-aminopelargonic acid
-
Corynebacterium glutamicum
7-Keto-8-aminopelargonic acid competitive with adenosyl-L-methionine Escherichia coli
adenine 8 mM Escherichia coli
adenosine 5 mM Escherichia coli
S-Adenosyl-L-(2-hydroxy-4-methylthio)butyric acid 2.5 mM Escherichia coli
S-adenosyl-L-ethionine 2 mM Escherichia coli
S-adenosyl-L-homocysteine 5 mM Escherichia coli
S-Inosyl-L-(2-hydroxy-4-methylthio)butyric acid 2 mM Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0012
-
8-Amino-7-oxononanoate pH 8.5, 37°C Escherichia coli
0.021
-
pyridoxamine 5'-phosphate pH 8.5, 37°C Escherichia coli
0.032
-
pyridoxal 5'-phosphate pH 8.5, 37°C Escherichia coli
0.2
-
S-adenosyl-L-methionine pH 8.5, 37°C Escherichia coli

Organism

Organism UniProt Comment Textmining
Corynebacterium glutamicum
-
NRRL 2311
-
Corynebacterium glutamicum NRRL 2311
-
NRRL 2311
-
Escherichia coli
-
-
-

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-(methylsulfanyl)-2-oxobutanoate + 7,8-diaminononanoate ping-pong mechanism Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Escherichia coli
additional information
-
-
Corynebacterium glutamicum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine + 7-amino-8-oxononanoate 1% of the activity of 8-amino-7-oxononanoate Escherichia coli S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 7-amino-8-oxononanoate 1% of the activity of 8-amino-7-oxononanoate Corynebacterium glutamicum S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 7-amino-8-oxononanoate 1% of the activity of 8-amino-7-oxononanoate Corynebacterium glutamicum NRRL 2311 S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate synonym: 7-keto-8-aminopelargonic acid, KAPA Escherichia coli S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate synonym: 7-keto-8-aminopelargonic acid, KAPA Corynebacterium glutamicum S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?
S-adenosyl-L-methionine + 8-amino-7-oxononanoate synonym: 7-keto-8-aminopelargonic acid, KAPA Corynebacterium glutamicum NRRL 2311 S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
Escherichia coli
37
-
-
Corynebacterium glutamicum

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.283
-
8-Amino-7-oxononanoate pH 8.5, 37°C Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
Escherichia coli
8.5
-
-
Corynebacterium glutamicum

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate cofactor Escherichia coli
pyridoxal 5'-phosphate cofactor Corynebacterium glutamicum
pyridoxal 5'-phosphate Km: 0.032 mM Escherichia coli
pyridoxamine 5'-phosphate Km: 0.021 mM Escherichia coli
pyridoxamine 5'-phosphate active as cofactor Escherichia coli
pyridoxamine 5'-phosphate active as cofactor Corynebacterium glutamicum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.025
-
7-Keto-8-aminopelargonic acid pH 8.5, 37°C Escherichia coli