Literature summary for 2.6.1.57 extracted from

Romagnoli, G.; Knijnenburg, T.A.; Liti, G.; Louis, E.J.; Pronk, J.T.; Daran, J.M.
Deletion of the Saccharomyces cerevisiae ARO8 gene, encoding an aromatic amino acid transaminase, enhances phenylethanol production from glucose (2015), Yeast, 32, 29-45.

Search for more literature for 2.6.1.57

Application

Application	Comment	Organism
synthesis	deletion of the Aro8 gene stimulates phenylethanol production when combined with other mutations that deregulate aromatic amino acid biosynthesis, i.e. expression of phenylalanine and tyrosine feedback-insensitive DAHP synthase. The resulting engineered Saccharomyces cerevisiae strain produces more than 3 mM phenylethanol from glucose during growth on a simple synthetic medium	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	P53090	-	-

Synonyms

Synonyms	Comment	Organism
Aro8	-	Saccharomyces cerevisiae

General Information

General Information	Comment	Organism
physiological function	mutation in Aro8 leads to substantial changes in the absolute and relative intracellular concentrations of amino acids. Deletion of Aro8 leads to de novo production of phenylethanol during growth on a glucose synthetic medium with ammonium as the sole nitrogen source. The mutation also stimulates phenylethanol production when combined with other mutations that deregulate aromatic amino acid biosynthesis	Saccharomyces cerevisiae

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)