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Literature summary for 2.6.1.57 extracted from

  • Berger, B.J.; Dai, W.W.; Wang, H.; Stark, R.E.; Cerami, A.
    Aromatic amino acid transamination and methionine recycling in trypanosomatids (1996), Proc. Natl. Acad. Sci. USA, 93, 4126-4130.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.6.1.57

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.33
-
 alpha-ketomethiobutyrate 37°C Trypanosoma brucei
0.33
-
 alpha-ketomethiobutyrate 37°C Crithidia fasciculata
0.57
-
 L-tyrosine 37°C Trypanosoma brucei
0.57
-
 L-tyrosine 37°C Crithidia fasciculata
1.64
-
 L-tryptophan 37°C Trypanosoma brucei
1.64
-
 L-tryptophan 37°C Crithidia fasciculata
2.18
-
 phenylalanine 37°C Trypanosoma brucei
2.18
-
 phenylalanine 37°C Crithidia fasciculata

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
alpha-ketomethiobutyrate + phenylalanine Trypanosoma brucei best amino donor methionine + phenylpyruvate
-
 ?
alpha-ketomethiobutyrate + phenylalanine Crithidia fasciculata best amino donor methionine + phenylpyruvate
-
 ?
alpha-ketomethiobutyrate + tryptophan Trypanosoma brucei
-
 methionine + indolepyruvate
-
 ?
alpha-ketomethiobutyrate + tryptophan Crithidia fasciculata
-
 methionine + indolepyruvate
-
 ?
alpha-ketomethiobutyrate + tyrosine Trypanosoma brucei probably involved in the recycling of methionine after the synthesis of polyamines methionine + hydroxyphenylpyruvate
-
 ?
alpha-ketomethiobutyrate + tyrosine Crithidia fasciculata probably involved in the recycling of methionine after the synthesis of polyamines methionine + hydroxyphenylpyruvate
-
 ?

Organism

Organism UniProt Comment Textmining
Crithidia fasciculata
-
-
-
Mus musculus
-
-
-
Trypanosoma brucei
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-ketomethiobutyrate + L-glutamine best amino donor Mus musculus 2-oxoglutaramide + L-methionine
-
 ?
alpha-ketomethiobutyrate + L-glutamine 18% of activity with phenylalanine Trypanosoma brucei 2-oxoglutaramide + L-methionine
-
 ?
alpha-ketomethiobutyrate + L-glutamine 36% of activity with phenylalanine Crithidia fasciculata 2-oxoglutaramide + L-methionine
-
 ?
alpha-ketomethiobutyrate + L-phenylalanine
-
 Mus musculus L-methionine + phenylpyruvate
-
 ?
alpha-ketomethiobutyrate + L-phenylalanine best amino donor Trypanosoma brucei L-methionine + phenylpyruvate
-
 ?
alpha-ketomethiobutyrate + L-phenylalanine best amino donor Crithidia fasciculata L-methionine + phenylpyruvate
-
 ?
alpha-ketomethiobutyrate + L-tryptophan
-
 Mus musculus L-methionine + indolepyruvate
-
 ?
alpha-ketomethiobutyrate + L-tryptophan
-
 Trypanosoma brucei L-methionine + indolepyruvate
-
 ?
alpha-ketomethiobutyrate + L-tryptophan
-
 Crithidia fasciculata L-methionine + indolepyruvate
-
 ?
alpha-ketomethiobutyrate + L-tyrosine
-
 Mus musculus L-methionine + hydroxyphenylpyruvate
-
 ?
alpha-ketomethiobutyrate + L-tyrosine
-
 Trypanosoma brucei L-methionine + hydroxyphenylpyruvate
-
 ?
alpha-ketomethiobutyrate + L-tyrosine
-
 Crithidia fasciculata L-methionine + hydroxyphenylpyruvate
-
 ?
alpha-ketomethiobutyrate + phenylalanine best amino donor Trypanosoma brucei methionine + phenylpyruvate
-
 ?
alpha-ketomethiobutyrate + phenylalanine best amino donor Crithidia fasciculata methionine + phenylpyruvate
-
 ?
alpha-ketomethiobutyrate + tryptophan
-
 Trypanosoma brucei methionine + indolepyruvate
-
 ?
alpha-ketomethiobutyrate + tryptophan
-
 Crithidia fasciculata methionine + indolepyruvate
-
 ?
alpha-ketomethiobutyrate + tyrosine probably involved in the recycling of methionine after the synthesis of polyamines Trypanosoma brucei methionine + hydroxyphenylpyruvate
-
 ?
alpha-ketomethiobutyrate + tyrosine probably involved in the recycling of methionine after the synthesis of polyamines Crithidia fasciculata methionine + hydroxyphenylpyruvate
-
 ?
arginine + alpha-ketomethiobutyrate
-
 Crithidia fasciculata ? + methionine
-
 ?
L-alanine + alpha-ketomethiobutyrate
-
 Trypanosoma brucei pyruvate + L-methionine
-
 ?
L-alanine + alpha-ketomethiobutyrate
-
 Crithidia fasciculata pyruvate + L-methionine
-
 ?
L-aspartate + alpha-ketomethiobutyrate
-
 Trypanosoma brucei oxaloacetate + L-methionine
-
 ?
L-aspartate + alpha-ketomethiobutyrate
-
 Crithidia fasciculata oxaloacetate + L-methionine
-
 ?
L-cysteine + alpha-ketomethiobutyrate
-
 Trypanosoma brucei 2-oxo-3-thiopropanoate + L-methionine
-
 ?
L-cysteine + alpha-ketomethiobutyrate
-
 Crithidia fasciculata 2-oxo-3-thiopropanoate + L-methionine
-
 ?
L-histidine + alpha-ketomethiobutyrate
-
 Crithidia fasciculata 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-methionine
-
 ?
L-isoleucine + alpha-ketomethiobutyrate
-
 Crithidia fasciculata 3-methyl-2-oxo-pentanoate + L-methionine
-
 ?
L-lysine + alpha-ketomethiobutyrate
-
 Crithidia fasciculata 2-oxo-6-amino-hexanoate + L-methionine
-
 ?
L-valine + alpha-ketomethiobutyrate
-
 Crithidia fasciculata 3-methyl-2-oxo-butanoate + L-methionine
-
 ?

Cofactor

Cofactor Comment Organism Structure
pyridoxamine 5'-phosphate
-
 Mus musculus
pyridoxamine 5'-phosphate
-
 Trypanosoma brucei
pyridoxamine 5'-phosphate
-
 Crithidia fasciculata