Application | Comment | Organism |
---|---|---|
pharmacology | 2-deoxystreptamine is a component of numerous clinically important antibiotics such as gentamicin, neomycin, tobramycin, amikacin and hygromycin | Micromonospora echinospora |
General Stability | Organism |
---|---|
activity rapidly lost when dialyzed | Micromonospora echinospora |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5,5'-dithio-bis(2-nitrobenzoic acid) | reduces specific activity by 50% | Micromonospora echinospora | |
p-hydroxymercuribenzoate | reduces specific activity by 50% | Micromonospora echinospora |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
64000 | 76000 | gel filtration | Micromonospora echinospora |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone | Micromonospora echinospora | 2-deoxystreptamine biosynthesis | 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Micromonospora echinospora | - |
ATCC 15835 | - |
Purification (Comment) | Organism |
---|---|
- |
Micromonospora echinospora |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
mycelium | - |
Micromonospora echinospora | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.24 | - |
- |
Micromonospora echinospora |
Storage Stability | Organism |
---|---|
-20°C, stored at concentrations greater than 1mg/ml, stable for several months with little loss of activity | Micromonospora echinospora |
4°C, inactivated within 1 month | Micromonospora echinospora |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-deoxystreptamine + 2-ketoglutaramate | - |
Micromonospora echinospora | 2-deoxy-keto-inosamine + L-glutamine | - |
r | |
2-deoxystreptamine + 2-oxoglutaramate | - |
Micromonospora echinospora | 2-deoxy-scyllo-inositol + L-glutamine | - |
r | |
2-deoxystreptamine + keto-scyllo-inositol | - |
Micromonospora echinospora | 2-deoxy-scyllo-inositol + amino-deoxy-keto-scyllo-inositol | - |
r | |
aminodeoxy-scyllo-inositol + 2-oxoglutaramate | - |
Micromonospora echinospora | scyllo-inositol + L-glutamine | - |
r | |
aminodeoxy-scyllo-inositol + keto-scyllo-inositol | - |
Micromonospora echinospora | amino-scyllo-inositol + aminodeoxy-keto-scyllo-inositol | - |
r | |
L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone | keto-scyllo-inositol | Micromonospora echinospora | 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol | - |
r | |
L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone | 2-deoxystreptamine biosynthesis | Micromonospora echinospora | 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol | - |
r | |
L-glutamine + 2-oxoadipate | - |
Micromonospora echinospora | 2-oxoglutaramate + L-2-amino-1,6-hexandioate | - |
r | |
L-glutamine + 2-oxobutyrate | - |
Micromonospora echinospora | 2-oxoglutaramate + 2-aminobutyrate | - |
r | |
L-glutamine + 2-oxocaproate | - |
Micromonospora echinospora | 2-oxoglutaramate + L-norleucine | - |
r | |
L-glutamine + 2-oxoglutaramate | - |
Micromonospora echinospora | 2-oxoglutaramate + L-glutamine | - |
r | |
L-glutamine + 2-oxoglutarate | - |
Micromonospora echinospora | 2-oxoglutaramate + L-glutamate | - |
r | |
L-glutamine + 2-oxovalerate | - |
Micromonospora echinospora | 2-oxoglutaramate + L-norvaline | - |
r | |
L-glutamine + DL-epi-inosose | - |
Micromonospora echinospora | 2-oxoglutaramate + amino-deoxy-inosose | - |
r | |
L-glutamine + glyoxalate | - |
Micromonospora echinospora | 2-oxoglutaramate + glycine | - |
r | |
L-glutamine + oxaloacetate | - |
Micromonospora echinospora | 2-oxoglutaramate + L-aspartate | - |
r | |
L-glutamine + pyruvate | - |
Micromonospora echinospora | 2-oxoglutaramate + L-alanine | - |
r | |
N3-methyl-2-deoxy-streptamine + keto-scyllo-inositol | - |
Micromonospora echinospora | 3-methylamino-2-deoxy-scyllo-inositol + 1-amino-1-deoxy-scyllo-inositol | - |
r | |
N3-methyl-2-deoxystreptamine + 2-oxoglutaramate | - |
Micromonospora echinospora | 3-methylamino-2-deoxy-scyllo-inositol + L-glutamine | - |
r | |
streptamine + 2-oxoglutaramate | - |
Micromonospora echinospora | amino-scyllo-inositol + L-glutamine | - |
r | |
streptamine + keto-scyllo-inositol | - |
Micromonospora echinospora | amino-scyllo-inositol + amino-deoxy-keto-scyllo-inositol | - |
r |
Synonyms | Comment | Organism |
---|---|---|
aminocyclitol aminotransferase | - |
Micromonospora echinospora |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
50 | - |
heat labile, loses all activity upon incubation for 20 min | Micromonospora echinospora |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8.5 | - |
Micromonospora echinospora |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7.5 | 9 | - |
Micromonospora echinospora |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Micromonospora echinospora |