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Literature summary for 2.6.1.50 extracted from

  • Lucher, L.A.; Chen, Y.M.; Walker, J.B.
    Reactions catalyzed by purified L-glutamine:keto-scyllo-inositol aminotransferase, an enzyme required for biosynthesis of aminocyclitol antibiotics (1989), Antimicrob. Agents Chemother., 33, 452-459.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
pharmacology 2-deoxystreptamine is a component of numerous clinically important antibiotics such as gentamicin, neomycin, tobramycin, amikacin and hygromycin Micromonospora echinospora

General Stability

General Stability Organism
activity rapidly lost when dialyzed Micromonospora echinospora

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithio-bis(2-nitrobenzoic acid) reduces specific activity by 50% Micromonospora echinospora
p-hydroxymercuribenzoate reduces specific activity by 50% Micromonospora echinospora

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
64000 76000 gel filtration Micromonospora echinospora

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone Micromonospora echinospora 2-deoxystreptamine biosynthesis 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol
-
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Organism

Organism UniProt Comment Textmining
Micromonospora echinospora
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ATCC 15835
-

Purification (Commentary)

Purification (Comment) Organism
-
Micromonospora echinospora

Source Tissue

Source Tissue Comment Organism Textmining
mycelium
-
Micromonospora echinospora
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.24
-
-
Micromonospora echinospora

Storage Stability

Storage Stability Organism
-20°C, stored at concentrations greater than 1mg/ml, stable for several months with little loss of activity Micromonospora echinospora
4°C, inactivated within 1 month Micromonospora echinospora

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-deoxystreptamine + 2-ketoglutaramate
-
Micromonospora echinospora 2-deoxy-keto-inosamine + L-glutamine
-
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2-deoxystreptamine + 2-oxoglutaramate
-
Micromonospora echinospora 2-deoxy-scyllo-inositol + L-glutamine
-
r
2-deoxystreptamine + keto-scyllo-inositol
-
Micromonospora echinospora 2-deoxy-scyllo-inositol + amino-deoxy-keto-scyllo-inositol
-
r
aminodeoxy-scyllo-inositol + 2-oxoglutaramate
-
Micromonospora echinospora scyllo-inositol + L-glutamine
-
r
aminodeoxy-scyllo-inositol + keto-scyllo-inositol
-
Micromonospora echinospora amino-scyllo-inositol + aminodeoxy-keto-scyllo-inositol
-
r
L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone keto-scyllo-inositol Micromonospora echinospora 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol
-
r
L-glutamine + 2,4,6/3,5-pentahydroxycyclohexanone 2-deoxystreptamine biosynthesis Micromonospora echinospora 2-oxoglutaramate + 1-amino-1-deoxy-scyllo-inositol
-
r
L-glutamine + 2-oxoadipate
-
Micromonospora echinospora 2-oxoglutaramate + L-2-amino-1,6-hexandioate
-
r
L-glutamine + 2-oxobutyrate
-
Micromonospora echinospora 2-oxoglutaramate + 2-aminobutyrate
-
r
L-glutamine + 2-oxocaproate
-
Micromonospora echinospora 2-oxoglutaramate + L-norleucine
-
r
L-glutamine + 2-oxoglutaramate
-
Micromonospora echinospora 2-oxoglutaramate + L-glutamine
-
r
L-glutamine + 2-oxoglutarate
-
Micromonospora echinospora 2-oxoglutaramate + L-glutamate
-
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L-glutamine + 2-oxovalerate
-
Micromonospora echinospora 2-oxoglutaramate + L-norvaline
-
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L-glutamine + DL-epi-inosose
-
Micromonospora echinospora 2-oxoglutaramate + amino-deoxy-inosose
-
r
L-glutamine + glyoxalate
-
Micromonospora echinospora 2-oxoglutaramate + glycine
-
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L-glutamine + oxaloacetate
-
Micromonospora echinospora 2-oxoglutaramate + L-aspartate
-
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L-glutamine + pyruvate
-
Micromonospora echinospora 2-oxoglutaramate + L-alanine
-
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N3-methyl-2-deoxy-streptamine + keto-scyllo-inositol
-
Micromonospora echinospora 3-methylamino-2-deoxy-scyllo-inositol + 1-amino-1-deoxy-scyllo-inositol
-
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N3-methyl-2-deoxystreptamine + 2-oxoglutaramate
-
Micromonospora echinospora 3-methylamino-2-deoxy-scyllo-inositol + L-glutamine
-
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streptamine + 2-oxoglutaramate
-
Micromonospora echinospora amino-scyllo-inositol + L-glutamine
-
r
streptamine + keto-scyllo-inositol
-
Micromonospora echinospora amino-scyllo-inositol + amino-deoxy-keto-scyllo-inositol
-
r

Synonyms

Synonyms Comment Organism
aminocyclitol aminotransferase
-
Micromonospora echinospora

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
heat labile, loses all activity upon incubation for 20 min Micromonospora echinospora

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8.5
-
Micromonospora echinospora

pH Range

pH Minimum pH Maximum Comment Organism
7.5 9
-
Micromonospora echinospora

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Micromonospora echinospora