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Literature summary for 2.6.1.44 extracted from
- Consequences of missense mutations for dimerization and turnover of alanine:glyoxylate aminotransferase: study of a spectrum of mutations (2006), Mol. Genet. Metab., 89, 349-359.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| A112D | less than 5% of the specific activity of the wild type enzyme | Homo sapiens |
| C173Y | less than 5% of the specific activity of the wild type enzyme | Homo sapiens |
| D183N | less than 5% of the specific activity of the wild type enzyme | Homo sapiens |
| G156R | less than 5% of the specific activity of the wild type enzyme | Homo sapiens |
| G161R | less than 5% of the specific activity of the wild type enzyme | Homo sapiens |
| G170R | 42% of the specific activity of the wild type enzyme | Homo sapiens |
| G41R | 24% of the specific activity of the wild type enzyme | Homo sapiens |
| G41V | 18% of the specific activity of the wild type enzyme | Homo sapiens |
| G82E | less than 5% of the specific activity of the wild type enzyme | Homo sapiens |
| K209R | less than 5% of the specific activity of the wild type enzyme | Homo sapiens |
| S187F | less than 5% of the specific activity of the wild type enzyme | Homo sapiens |
| S205P | less than 5% of the specific activity of the wild type enzyme | Homo sapiens |
| S218L | less than 5% of the specific activity of the wild type enzyme | Homo sapiens |
| W108R | less than 5% of the specific activity of the wild type enzyme | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| peroxisome | - |
Homo sapiens | 5777 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 48600 | - |
SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-alanine + glyoxylate | - |
Homo sapiens | pyruvate + glycine | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AGT | - |
Homo sapiens |
| alanine:glyoxylate aminotransferase type 1 | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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