Literature summary for 2.6.1.42 extracted from

Bertrand, S.M.; Ancellin, N.; Beaufils, B.; Bingham, R.P.; Borthwick, J.A.; Boullay, A.B.; Boursier, E.; Carter, P.S.; Chung, C.W.; Churcher, I.; Dodic, N.; Fouchet, M.H.; Fournier, C.; Francis, P.L.; Gummer, L.A.; Herry, K.; Hobbs, A.; Hobbs, C.I.; Homes, P.; Jamieson, C.; Nicodeme, E.; Pickett, S.D.; Reid, I.
The discovery of in vivo active mitochondrial branched-chain aminotransferase (BCATm) inhibitors by hybridizing fragment and HTS hits (2015), J. Med. Chem., 58, 7140-7163.

Inhibitors

Inhibitors	Comment	Organism	Structure
2-((4-chloro-2,6-difluorobenzyl)amino)-7-oxo-5-propyl-4,7-dihydropyrazolo[1,5-a]-pyrimidine-3-carbonitrile	oral administration of the compound significantly raises the circulating levels of the branched-chain amino acids leucine, isoleucine, and valine. Compound demonstrates a good dose response, with leucine increasing from 473 microM (basal level) to 1.2 mM in 100 mg/kg treated mice	Mus musculus

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Mus musculus	5739	-

Organism	UniProt	Comment	Textmining
Mus musculus	O35855	-	-

Synonyms	Comment	Organism
Bcat2	-	Mus musculus
BCATm	-	Mus musculus

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Release 2023.1 (January 2023)