Literature summary for 2.6.1.42 extracted from

Hutson, S.M.; Berkich, D.; Drown, P.; Xu, B.; Aschner, M.; LaNoue, K.F.
Role of branched-chain aminotransferase isoenzymes and gabapentin in neurotransmitter metabolism (1998), J. Neurochem., 71, 863-874.

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Inhibitors

Inhibitors	Comment	Organism	Structure
gabapentin	structural analogue of leucine, competitive inhibitor of BCATc, does not inhibit BCATm	Homo sapiens
gabapentin	structural analogue of leucine, competitive inhibitor of BCATc, does not inhibit BCATm	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-
cytosol	-	Rattus norvegicus	5829	-
mitochondrion	-	Homo sapiens	5739	-
mitochondrion	-	Rattus norvegicus	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-isoleucine + 2-oxoglutarate	Homo sapiens	-	3-methyl-2-oxopentanoate + L-glutamate	-	r
L-isoleucine + 2-oxoglutarate	Rattus norvegicus	-	3-methyl-2-oxopentanoate + L-glutamate	-	r
L-leucine + 2-oxoglutarate	Homo sapiens	-	4-methyl-2-oxopentanoate + L-glutamate	-	?
L-leucine + 2-oxoglutarate	Rattus norvegicus	first step in the metabolism of branched-chain amino acids	4-methyl-2-oxopentanoate + L-glutamate	-	r
L-valine + 2-oxoglutarate	Rattus norvegicus	-	3-methyl-2-oxobutanoate + L-glutamate	-	r

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	human	-
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining
astrocyte	-	Rattus norvegicus	-
brain	-	Rattus norvegicus	-
neuron	-	Rattus norvegicus	-
ovary	-	Rattus norvegicus	-
placenta	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-isoleucine + 2-oxoglutarate	-	Homo sapiens	3-methyl-2-oxopentanoate + L-glutamate	-	r
L-isoleucine + 2-oxoglutarate	-	Rattus norvegicus	3-methyl-2-oxopentanoate + L-glutamate	-	r
L-leucine + 2-oxoglutarate	-	Homo sapiens	4-methyl-2-oxopentanoate + L-glutamate	-	?
L-leucine + 2-oxoglutarate	-	Homo sapiens	4-methyl-2-oxopentanoate + L-glutamate	-	r
L-leucine + 2-oxoglutarate	-	Rattus norvegicus	4-methyl-2-oxopentanoate + L-glutamate	-	r
L-leucine + 2-oxoglutarate	first step in the metabolism of branched-chain amino acids	Rattus norvegicus	4-methyl-2-oxopentanoate + L-glutamate	-	r
L-valine + 2-oxoglutarate	-	Homo sapiens	3-methyl-2-oxobutanoate + L-glutamate	-	r
L-valine + 2-oxoglutarate	-	Rattus norvegicus	3-methyl-2-oxobutanoate + L-glutamate	-	r

Synonyms

Synonyms	Comment	Organism
BCATc	-	Homo sapiens
BCATc	-	Rattus norvegicus
BCATm	-	Homo sapiens
BCATm	-	Rattus norvegicus

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Release 2023.1 (January 2023)