Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.6.1.39 extracted from

  • Deshmukh, D.R.; Mungre, S.M.
    Purification and properties of 2-aminoadipate: 2-oxoglutarate aminotransferase from bovine kidney (1989), Biochem. J., 261, 761-768.
    View publication on PubMedView publication on EuropePMC

General Stability

General Stability Organism
0.1 mM dithiothreitol improves the stability of the enzyme by 50% Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
3-methylglutaric acid 6 mM, 2% inhibition Bos taurus
3-methylglutaric acid 6 mM, 38% inhibition Rattus norvegicus
adipic acid 6 mM, 48% inhibition Bos taurus
adipic acid 6 mM, 60% inhibition Rattus norvegicus
azelaic acid 6 mM, 36% inhibition Bos taurus
azelaic acid 6 mM, 38% inhibition Rattus norvegicus
Decanoic acid 6 mM, 50% inhibition Bos taurus
Decanoic acid 6 mM, 45% inhibition Rattus norvegicus
Diethylglutaric acid 6 mM, 20% inhibition Bos taurus
Diethylglutaric acid 6 mM, 20% inhibition Rattus norvegicus
dimethylglutaric acid 6 mM, 15% inhibition Bos taurus
dimethylglutaric acid 6 mM, 42% inhibition Rattus norvegicus
Glutaric acid 6 mM, 5% inhibition Rattus norvegicus
Kynurenic acid 1 mM, 30% inhibition Bos taurus
Kynurenic acid 1 mM, 40% inhibition Rattus norvegicus
additional information oxaloacetic acid is no inhibitor Bos taurus
additional information oxaloacetic acid is no inhibitor Rattus norvegicus
pimelic acid 6 mM, 28% inhibition Bos taurus
pimelic acid 6 mM, 32% inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.5
-
2-oxoadipic acid pH 7.0, 37°C Rattus norvegicus
0.5
-
2-oxoadipic acid pH 7.0, 37°C Bos taurus
4.6
-
L-Glutamic acid pH 7.0, 37°C Rattus norvegicus
4.6
-
L-Glutamic acid pH 7.0, 37°C Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Rattus norvegicus 5737
-
cytoplasm
-
Bos taurus 5737
-
mitochondrion
-
Rattus norvegicus 5739
-
mitochondrion
-
Bos taurus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
41000
-
2 * 41000, SDS-PAGE Rattus norvegicus
41000
-
2 * 41000, SDS-PAGE Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-2-aminoadipate + 2-oxoglutarate Rattus norvegicus lysine catabolic pathway 2-oxoadipate + L-glutamate
-
r
L-2-aminoadipate + 2-oxoglutarate Bos taurus lysine catabolic pathway 2-oxoadipate + L-glutamate
-
r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
bovine
-
Rattus norvegicus
-
Sprague-Dawley
-
Rattus norvegicus Sprague-Dawley
-
Sprague-Dawley
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-
kidney
-
Bos taurus
-
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.53
-
-
Bos taurus

Storage Stability

Storage Stability Organism
4°C, partially purified enzyme in 8 mM potassium phosphate buffer, pH 7.1, 100% activity is lost when stored for 14 days Bos taurus
4°C, partially purified enzyme in 8 mM potassium phosphate buffer, pH 7.1, 15% activity is lost when stored for 14 days Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-aminoadipate + pyruvate
-
Rattus norvegicus 2-oxoadipate + L-alanine
-
r
2-aminoadipate + pyruvate
-
Bos taurus 2-oxoadipate + L-alanine
-
r
3,5-di-iodotyrosine + 2-oxoglutarate
-
Rattus norvegicus 3,5-diiodophenylpyruvate + L-glutamate
-
r
3,5-di-iodotyrosine + 2-oxoglutarate
-
Bos taurus 3,5-diiodophenylpyruvate + L-glutamate
-
r
DL-2-aminopimelic acid + 2-oxoglutarate
-
Rattus norvegicus 2-oxoadipate + L-glutamate
-
r
DL-2-aminopimelic acid + 2-oxoglutarate
-
Bos taurus 2-oxoadipate + L-glutamate
-
r
kynurenine + 2-oxoglutarate
-
Rattus norvegicus kynurenic acid + L-glutamate
-
ir
L-2-aminoadipate + 2-oxoglutarate
-
Rattus norvegicus 2-oxoadipate + L-glutamate
-
r
L-2-aminoadipate + 2-oxoglutarate
-
Bos taurus 2-oxoadipate + L-glutamate
-
r
L-2-aminoadipate + 2-oxoglutarate lysine catabolic pathway Rattus norvegicus 2-oxoadipate + L-glutamate
-
r
L-2-aminoadipate + 2-oxoglutarate lysine catabolic pathway Bos taurus 2-oxoadipate + L-glutamate
-
r
L-histidine + 2-oxoglutarate
-
Rattus norvegicus 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate
-
r
L-histidine + 2-oxoglutarate
-
Bos taurus 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate
-
r
L-histidine + 2-oxoglutarate
-
Rattus norvegicus Sprague-Dawley 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-glutamate
-
r
L-histidine + pyruvate
-
Rattus norvegicus 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
-
r
L-histidine + pyruvate
-
Bos taurus 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
-
r
L-histidine + pyruvate
-
Rattus norvegicus Sprague-Dawley 3-(1H-imidazol-4-yl)-2-oxopropanoate + L-alanine
-
r
L-norleucine + 2-oxoglutarate
-
Rattus norvegicus 2-oxohexanoate + L-glutamate
-
r
L-norleucine + 2-oxoglutarate
-
Bos taurus 2-oxohexanoate + L-glutamate
-
r
L-norleucine + 2-oxoglutarate
-
Rattus norvegicus Sprague-Dawley 2-oxohexanoate + L-glutamate
-
r
additional information only slight activity with phenylalanine, tryptophan, tyrosine, aspartate or alanine as amino group donors, glyoxylate is no amino group acceptor Rattus norvegicus ?
-
?
additional information only slight activity with phenylalanine, tryptophan, tyrosine, aspartate or alanine as amino group donors, glyoxylate is no amino group acceptor Bos taurus ?
-
?
additional information no kynurenine aminotransferase activity Bos taurus ?
-
?
additional information 2-aminoadipate aminotransferase and kynurenine aminotransferase, EC 2.6.1.7, activities are properties of a single protein Rattus norvegicus ?
-
?
additional information only slight activity with phenylalanine, tryptophan, tyrosine, aspartate or alanine as amino group donors, glyoxylate is no amino group acceptor Rattus norvegicus Sprague-Dawley ?
-
?
additional information 2-aminoadipate aminotransferase and kynurenine aminotransferase, EC 2.6.1.7, activities are properties of a single protein Rattus norvegicus Sprague-Dawley ?
-
?

Subunits

Subunits Comment Organism
dimer 2 * 41000, SDS-PAGE Rattus norvegicus
dimer 2 * 41000, SDS-PAGE Bos taurus

Synonyms

Synonyms Comment Organism
AadAT
-
Rattus norvegicus
AadAT
-
Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Rattus norvegicus
7
-
-
Bos taurus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Rattus norvegicus
pyridoxal 5'-phosphate
-
Bos taurus