Literature summary for 2.6.1.36 extracted from

Devi, P.; Sridevi, J.; Kakan, S.; Saxena, S.; Jeankumar, V.; Soni, V.; Anantaraju, H.; Yogeeswari, P.; Sriram, D.
Discovery of novel lysine ?-aminotransferase inhibitors: An intriguing potential target for latent tuberculosis. (2015), Tuberculosis, 95, 786-794.

Crystallization (Commentary)

Crystallization (Comment)	Organism
molecular docking of inhibitors 4-methoxy-2-(pyridin-4-yl)-2,3-dihydro-1,3-thiazole-5-carboxylic acid, 2-phenyl-4-(prop-2-yn-1-yloxy)-2,3-dihydro-1,3-thiazole-5-carboxylic acid, 4-ethoxy-2-phenyl-2,3-dihydro-1,3-thiazole-5-carboxamide. Ligands are found in the vicinity of the Arg422, Gln274, Lys300, Arg170, Phe167, Glu243 amino acid residues. Compounds can make favourable interactions with important amino acid residues such as Arg170, Arg440, and Lys300	Mycobacterium tuberculosis

Crystallization (Comment)

Organism

molecular docking of inhibitors 4-methoxy-2-(pyridin-4-yl)-2,3-dihydro-1,3-thiazole-5-carboxylic acid, 2-phenyl-4-(prop-2-yn-1-yloxy)-2,3-dihydro-1,3-thiazole-5-carboxylic acid, 4-ethoxy-2-phenyl-2,3-dihydro-1,3-thiazole-5-carboxamide. Ligands are found in the vicinity of the Arg422, Gln274, Lys300, Arg170, Phe167, Glu243 amino acid residues. Compounds can make favourable interactions with important amino acid residues such as Arg170, Arg440, and Lys300

Mycobacterium tuberculosis

Inhibitors

Inhibitors	Comment	Organism
2-phenyl-4-(prop-2-yn-1-yloxy)-2,3-dihydro-1,3-thiazole-5-carboxylic acid	-	Mycobacterium tuberculosis
4-ethoxy-2-phenyl-2,3-dihydro-1,3-thiazole-5-carboxamide	protein is stabilzed in presence of the inhibitor	Mycobacterium tuberculosis
4-methoxy-2-(pyridin-4-yl)-2,3-dihydro-1,3-thiazole-5-carboxylic acid	at 0.05 mM, 24.87% cytotoxicity in a HEK-293 cell line	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	P9WQ77	-	-
Mycobacterium tuberculosis H37Rv	P9WQ77	-	-

Temperature Stability [°C]

Temperature Stability Minimum [°C]	Temperature Stability Maximum [°C]	Comment	Organism
50.6	-	melting temperature	Mycobacterium tuberculosis
52.1	-	melting temperature in presence of inhibitor 4-ethoxy-2-phenyl-2,3-dihydro-1,3-thiazole-5-carboxamide	Mycobacterium tuberculosis

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.0012	-	pH 7.2, 37°C	Mycobacterium tuberculosis	4-methoxy-2-(pyridin-4-yl)-2,3-dihydro-1,3-thiazole-5-carboxylic acid
0.0017	-	pH 7.2, 37°C	Mycobacterium tuberculosis	4-ethoxy-2-phenyl-2,3-dihydro-1,3-thiazole-5-carboxamide
0.0018	-	pH 7.2, 37°C	Mycobacterium tuberculosis	2-phenyl-4-(prop-2-yn-1-yloxy)-2,3-dihydro-1,3-thiazole-5-carboxylic acid