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Literature summary for 2.6.1.36 extracted from

  • Dube, D.; Tripathi, S.M.; Ramachandran, R.
    Identification of in vitro inhibitors of Mycobacterium tuberculosis lysine epsilon-aminotransferase by pharmacophore mapping and three-dimensional flexible searches (2008), Med. Chem. Res., 17, 182-188.
No PubMed abstract available

Crystallization (Commentary)

Crystallization (Comment) Organism
docking experiments based on crystal structure PDB code 2CJH in order to identify enzyme inhibitors Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
2-oxopentanedioic acid binding energy 6.48 kcal per mol Mycobacterium tuberculosis
2-[methyl[(1-methylpiperidin-2-yl)methyl]amino]-1-phenylethanol binding energy 7.23 kcal per mol Mycobacterium tuberculosis
N-([2-[2-(3,4-dimethoxyphenyl)ethyl]-1,3-dioxo-2,3,5,6,11,11a-hexahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indol-5-yl]methyl)-2-(4-methoxyphenyl)acetamide binding energy 10.79 kcal per mol Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WQ77
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