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Literature summary for 2.6.1.3 extracted from

  • Miyamoto, R.; Otsuguro, K.; Yamaguchi, S.; Ito, S.
    Contribution of cysteine aminotransferase and mercaptopyruvate sulfurtransferase to hydrogen sulfide production in peripheral neurons (2014), J. Neurochem., 130, 29-40.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
ganglion dorsal root ganglion Rattus norvegicus
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neuron peripheral neuron Rattus norvegicus
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PC-12 cell pheochromocytoma-derived cell Rattus norvegicus
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General Information

General Information Comment Organism
physiological function cystathionine beta-synthase, cysteine aminotransferase, and mercaptopyruvate sulfurtransferase, but not cystathionine gamma-lyase, are expressed in PC12 cells and the dorsal root ganglion, and appreciable amounts of H2S are produced from L-cysteine in the presence of alpha-ketoglutarate, together with dithiothreitol. The production of H2S is inhibited by cysteine aminotransferase inhibitor aminooxyacetic acid, and competitive cysteine aminotransferase substrates L-aspartate and oxaloacetate. The amount of H2S produced by cysteine aminotransferase/mercaptopyruvate sulfurtransferase at pH 8.0, a physiological mitochondrial matrix pH, is comparable to that produced by cystathionine beta-synthase and cystathionine beta-synthase in the liver and the brain, respectively Rattus norvegicus