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Literature summary for 2.6.1.28 extracted from

  • Schneider, P.; Weber, M.; Rosenberger, K.; Hoffmeister, D.
    A one-pot chemoenzymatic synthesis for the universal precursor of antidiabetes and antiviral bis-indolylquinones (2007), Chem. Biol., 14, 635-644.
    View publication on PubMed

Application

Application Comment Organism
synthesis one-pot synthesis of di-demethylasterriquinone D from L-tryptophan and phenylpyruvic acid by use of enzymes TdiA and TdiD Aspergillus nidulans

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Aspergillus nidulans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.43
-
phenylpyruvate pH 7.0, 48°C Aspergillus nidulans
3.02
-
L-tryptophan pH 7.0, 48°C Aspergillus nidulans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Aspergillus nidulans catalyzes the first enzymatic step specific to the metabolic pathway toward terrequinone A ?
-
?

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans A7XRY8
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + 4-hydroxyphenylpyruvate 15% of the activity with phenylpyruvate Aspergillus nidulans 3-indole-2-oxopropanoate + ?
-
?
L-tryptophan + phenylpyruvate
-
Aspergillus nidulans 3-indole-2-oxopropanoate + L-phenylalanine
-
?
additional information catalyzes the first enzymatic step specific to the metabolic pathway toward terrequinone A Aspergillus nidulans ?
-
?
additional information no amino acceptor substrate: pyruvic acid, 2-oxoglutaric acid, 2-oxo-butyric acid, 2-oxo-valeric acid Aspergillus nidulans ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
48
-
-
Aspergillus nidulans

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
9.1
-
phenylpyruvate pH 7.0, 48°C Aspergillus nidulans
19.3
-
L-tryptophan pH 7.0, 48°C Aspergillus nidulans

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Aspergillus nidulans