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Literature summary for 2.6.1.24 extracted from

  • Nakano, M.
    Purification and properties of halogenated tyrosine and thyroid hormone transaminase from rat kidney mitochondria (1967), J. Biol. Chem., 242, 73-81.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3,5-Diiodo-4-hydroxyphenyl-DL-lactic acid
-
Rattus norvegicus
3,5-Diiodo-4-hydroxyphenylacetate strong inhibition, mixed type Rattus norvegicus
4-chloromercuribenzoate
-
Rattus norvegicus
4-hydroxyphenyl-DL-lactic acid weak Rattus norvegicus
4-hydroxyphenylacetic acid
-
Rattus norvegicus
o-Iodosobenzoate
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1 1.3 3,5-diiodo-L-tyrosine pH 6.2, 37°C Rattus norvegicus
3.4 3.7 3,5-Dibromo-L-tyrosine pH 6.5, 37°C Rattus norvegicus
6.1
-
3,5-dichloro-L-tyrosine pH 6.-L-7, 37°C Rattus norvegicus
6.5
-
3-iodo-L-tyrosine pH 7.4, 37°C Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
80000
-
gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3,5-diiodo-L-tyrosine + 2-oxoglutarate Rattus norvegicus
-
3,5-diiodo-4-hydroxyphenylpyruvate + L-glutamate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
30fold Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.53
-
partially purified enzyme Rattus norvegicus

Storage Stability

Storage Stability Organism
0°C, 50 mM sodium phosphate buffer, 1 mM EDTA, 1 mM 2-mercaptoethanol, 0.15 M NaCl, approximately 4 mg protein/ml, 40% loss of activity after 1 week Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3,5-dibromo-L-tyrosine + 2-oxoglutarate at 127% the rate of 3,5-diiodo-L-tyrosine Rattus norvegicus 3,5-dibromo-4-hydroxyphenylpyruvate + L-glutamate
-
?
3,5-dichloro-L-tyrosine + 2-oxoglutarate at 110% the rate of 3,5-diiodo-L-tyrosine Rattus norvegicus 3,5-dichloro-4-hydroxyphenylpyruvate + L-glutamate
-
?
3,5-diiodo-L-tyrosine + 2-oxoglutarate
-
Rattus norvegicus 3,5-diiodo-4-hydroxyphenylpyruvate + L-glutamate
-
?
3,5-diiodo-L-tyrosine + 2-oxoglutarate specific for 2-oxoglutarate as amino acceptor Rattus norvegicus 3,5-diiodo-4-hydroxyphenylpyruvate + L-glutamate
-
?
3,5-diiodo-L-tyrosine + oxaloacetate 30% substitution of 2-oxoglutarate by oxaloacetate as amino acceptor Rattus norvegicus 3,5-diiodo-4-hydroxyphenylpyruvate + L-aspartate
-
?
3-(4-fluorophenyl)alanine + 2-oxoglutarate i.e. p-fluoro-DL-phenylalanine, at 3.1% the rate of 3,5-diiodo-L-tyrosine Rattus norvegicus (4-fluorophenyl)pyruvate + L-glutamate
-
?
3-iodo-L-tyrosine + 2-oxoglutarate at 76% the rate of 3,5-diiodo-L-tyrosine Rattus norvegicus 3-iodo-4-hydroxyphenylpyruvate + L-glutamate
-
?
L-phenylalanine + 2-oxoglutarate at 3.9% the rate of 3,5-diiodo-L-tyrosine Rattus norvegicus phenylpyruvate + L-glutamate
-
?
L-tryptophan + 2-oxoglutarate at 3.6% the rate of 3,5-diiodo-L-tyrosine Rattus norvegicus 3-indole-2-oxopropanoate + L-glutamate
-
?
L-tyrosine + 2-oxoglutarate at 3.9% the rate of 3,5-diiodo-L-tyrosine Rattus norvegicus (4-hydroxyphenyl)pyruvate + L-glutamate
-
?
additional information substrate specificity Rattus norvegicus ?
-
?
additional information no activity with: D-diiodotyrosine, tyrosine analogues with nitro, amino or hydroxy substituents in position 3 or 3 and 5 Rattus norvegicus ?
-
?
additional information no activity with pyruvate as amino acceptor Rattus norvegicus ?
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
with substrate diiodo-L-tyrosine Rattus norvegicus
6.5
-
with substrate dibromo-L-tyrosine, dichloro-L-tyrosine Rattus norvegicus
7 7.5 with substrate monoiodo-L-tyrosine Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate required Rattus norvegicus