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Literature summary for 2.6.1.21 extracted from
- Enzymatic asymmetric synthesis of enantiomerically pure aliphatic, aromatic and arylaliphatic amines with (R)-selective amine transaminases (2011), Adv. Synth. Catal., 353, 2439-2445.
No PubMed abstract available
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli | Penicillium chrysogenum |
| expressed in Escherichia coli | Aspergillus fischeri |
| expressed in Escherichia coli | Aspergillus oryzae |
| expressed in Escherichia coli | Aspergillus terreus |
| expressed in Escherichia coli | Aspergillus fumigatus |
| expressed in Escherichia coli | Fusarium graminearum |
| expressed in Escherichia coli | Mycolicibacterium vanbaalenii |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus fischeri | - |
- |
- |
| Aspergillus fumigatus | - |
- |
- |
| Aspergillus oryzae | - |
- |
- |
| Aspergillus terreus | - |
- |
- |
| Fusarium graminearum | - |
- |
- |
| Mycolicibacterium vanbaalenii | - |
- |
- |
| Penicillium chrysogenum | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-(4-nitrophenyl)ethanone + D-alanine | asymmetric synthesis, conversion: 1% | Penicillium chrysogenum | (1R)-1-(4-nitrophenyl)ethanamine + pyruvate | - |
? |  |
| 1-(4-nitrophenyl)ethanone + D-alanine | asymmetric synthesis, conversion: 17%, enantiomeric excess: 99% | Aspergillus terreus | (1R)-1-(4-nitrophenyl)ethanamine + pyruvate | - |
? | |
| 1-(4-nitrophenyl)ethanone + D-alanine | asymmetric synthesis, conversion: 3%, enantiomeric excess: 99% | Fusarium graminearum | (1R)-1-(4-nitrophenyl)ethanamine + pyruvate | - |
? | |
| 1-(4-nitrophenyl)ethanone + D-alanine | asymmetric synthesis, conversion: 6%, enantiomeric excess: 99% | Mycolicibacterium vanbaalenii | (1R)-1-(4-nitrophenyl)ethanamine + pyruvate | - |
? | |
| 1-(4-nitrophenyl)ethanone + D-alanine | asymmetric synthesis, conversion: 68%, enantiomeric excess: 99% | Aspergillus fumigatus | (1R)-1-(4-nitrophenyl)ethanamine + pyruvate | - |
? | |
| 1-(4-nitrophenyl)ethanone + D-alanine | asymmetric synthesis, conversion: 74%, enantiomeric excess: 99% | Aspergillus fischeri | (1R)-1-(4-nitrophenyl)ethanamine + pyruvate | - |
? | |
| 1-(4-nitrophenyl)ethanone + D-alanine | asymmetric synthesis, conversion: 8%, enantiomeric excess: 99% | Aspergillus oryzae | (1R)-1-(4-nitrophenyl)ethanamine + pyruvate | - |
? | |
| 1-cyclohexylethanone + D-alanine | asymmetric synthesis, conversion: 1% | Penicillium chrysogenum | (1R)-1-cyclohexylethanamine + pyruvate | - |
? | |
| 1-cyclohexylethanone + D-alanine | asymmetric synthesis, conversion: 16%, enantiomeric excess: 99% | Fusarium graminearum | (1R)-1-cyclohexylethanamine + pyruvate | - |
? | |
| 1-cyclohexylethanone + D-alanine | asymmetric synthesis, conversion: 30%, enantiomeric excess: 99% | Aspergillus terreus | (1R)-1-cyclohexylethanamine + pyruvate | - |
? | |
| 1-cyclohexylethanone + D-alanine | asymmetric synthesis, conversion: 53%, enantiomeric excess: 99% | Aspergillus oryzae | (1R)-1-cyclohexylethanamine + pyruvate | - |
? | |
| 1-cyclohexylethanone + D-alanine | asymmetric synthesis, conversion: 56%, enantiomeric excess: 99% | Mycolicibacterium vanbaalenii | (1R)-1-cyclohexylethanamine + pyruvate | - |
? | |
| 1-cyclohexylethanone + D-alanine | asymmetric synthesis, conversion: 59%, enantiomeric excess: 99% | Aspergillus fischeri | (1R)-1-cyclohexylethanamine + pyruvate | - |
? | |
| 1-cyclohexylethanone + D-alanine | asymmetric synthesis, conversion: 93%, enantiomeric excess: 99% | Aspergillus fumigatus | (1R)-1-cyclohexylethanamine + pyruvate | - |
? | |
| 1-phenylethanone + D-alanine | asymmetric synthesis, conversion: 1% | Penicillium chrysogenum | (1R)-1-phenylethanamine + pyruvate | - |
? | |
| 1-phenylethanone + D-alanine | asymmetric synthesis, conversion: 3%, enantiomeric excess: 99% | Aspergillus terreus | (1R)-1-phenylethanamine + pyruvate | - |
? | |
| 1-phenylethanone + D-alanine | asymmetric synthesis, conversion: 39%, enantiomeric excess: 99% | Aspergillus oryzae | (1R)-1-phenylethanamine + pyruvate | - |
? | |
| 1-phenylethanone + D-alanine | asymmetric synthesis, conversion: 4%, enantiomeric excess: 99% | Fusarium graminearum | (1R)-1-phenylethanamine + pyruvate | - |
? | |
| 1-phenylethanone + D-alanine | asymmetric synthesis, conversion: 42%, enantiomeric excess: 99% | Mycolicibacterium vanbaalenii | (1R)-1-phenylethanamine + pyruvate | - |
? | |
| 1-phenylethanone + D-alanine | asymmetric synthesis, conversion: 87%, enantiomeric excess: 99% | Aspergillus fischeri | (1R)-1-phenylethanamine + pyruvate | - |
? | |
| 1-phenylethanone + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus fumigatus | (1R)-1-phenylethanamine + pyruvate | - |
? | |
| 4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine | asymmetric synthesis, conversion: 1% | Penicillium chrysogenum | 5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate | - |
? | |
| 4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine | asymmetric synthesis, conversion: 6%, enantiomeric excess: 99% | Fusarium graminearum | 5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate | - |
? | |
| 4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine | asymmetric synthesis, conversion: 77%, enantiomeric excess: 99% | Aspergillus terreus | 5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate | - |
? | |
| 4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine | asymmetric synthesis, conversion: 85%, enantiomeric excess: 99% | Mycolicibacterium vanbaalenii | 5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate | - |
? | |
| 4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine | asymmetric synthesis, conversion: 94%, enantiomeric excess: 99% | Aspergillus fumigatus | 5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate | - |
? | |
| 4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine | asymmetric synthesis, conversion: 98%, enantiomeric excess: 99% | Aspergillus oryzae | 5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate | - |
? | |
| 4-(3-hydroxy-4-methoxyphenyl)butan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus fischeri | 5-[(3R)-3-aminobutyl]-2-methoxyphenol + pyruvate | - |
? | |
| 4-(4-hydroxyphenyl)butan-2-one + D-alanine | asymmetric synthesis, conversion: 1% | Penicillium chrysogenum | 4-[(3R)-3-aminobutyl]phenol + pyruvate | - |
? | |
| 4-(4-hydroxyphenyl)butan-2-one + D-alanine | asymmetric synthesis, conversion: 5%, enantiomeric excess: 99% | Fusarium graminearum | 4-[(3R)-3-aminobutyl]phenol + pyruvate | - |
? | |
| 4-(4-hydroxyphenyl)butan-2-one + D-alanine | asymmetric synthesis, conversion: 71%, enantiomeric excess: 99% | Mycolicibacterium vanbaalenii | 4-[(3R)-3-aminobutyl]phenol + pyruvate | - |
? | |
| 4-(4-hydroxyphenyl)butan-2-one + D-alanine | asymmetric synthesis, conversion: 83%, enantiomeric excess: 99% | Aspergillus terreus | 4-[(3R)-3-aminobutyl]phenol + pyruvate | - |
? | |
| 4-(4-hydroxyphenyl)butan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus fischeri | 4-[(3R)-3-aminobutyl]phenol + pyruvate | - |
? | |
| 4-(4-hydroxyphenyl)butan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus oryzae | 4-[(3R)-3-aminobutyl]phenol + pyruvate | - |
? | |
| 4-(4-hydroxyphenyl)butan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus fumigatus | 4-[(3R)-3-aminobutyl]phenol + pyruvate | - |
? | |
| 4-(4-methoxyphenyl)butan-2-one + D-alanine | asymmetric synthesis, conversion: 1% | Penicillium chrysogenum | (2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate | - |
? | |
| 4-(4-methoxyphenyl)butan-2-one + D-alanine | asymmetric synthesis, conversion: 20%, enantiomeric excess: 99% | Aspergillus terreus | (2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate | - |
? | |
| 4-(4-methoxyphenyl)butan-2-one + D-alanine | asymmetric synthesis, conversion: 7%, enantiomeric excess: 99% | Fusarium graminearum | (2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate | - |
? | |
| 4-(4-methoxyphenyl)butan-2-one + D-alanine | asymmetric synthesis, conversion: 72%, enantiomeric excess: 99% | Mycolicibacterium vanbaalenii | (2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate | - |
? | |
| 4-(4-methoxyphenyl)butan-2-one + D-alanine | asymmetric synthesis, conversion: 92%, enantiomeric excess: 99% | Aspergillus fischeri | (2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate | - |
? | |
| 4-(4-methoxyphenyl)butan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus oryzae | (2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate | - |
? | |
| 4-(4-methoxyphenyl)butan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus fumigatus | (2R)-2-amino-4-(4-methoxyphenyl)butane + pyruvate | - |
? | |
| 4-methylpentan-2-one + D-alanine | asymmetric synthesis, conversion: 32%, enantiomeric excess: 99% | Fusarium graminearum | (2R)-2-amino-4-methylpentane + pyruvate | - |
? | |
| 4-methylpentan-2-one + D-alanine | asymmetric synthesis, conversion: 64%, enantiomeric excess: 99% | Aspergillus terreus | (2R)-2-amino-4-methylpentane + pyruvate | - |
? | |
| 4-methylpentan-2-one + D-alanine | asymmetric synthesis, conversion: 68%, enantiomeric excess: 99% | Mycolicibacterium vanbaalenii | (2R)-2-amino-4-methylpentane + pyruvate | - |
? | |
| 4-methylpentan-2-one + D-alanine | asymmetric synthesis, conversion: 79%, enantiomeric excess: 99% | Aspergillus oryzae | (2R)-2-amino-4-methylpentane + pyruvate | - |
? | |
| 4-methylpentan-2-one + D-alanine | asymmetric synthesis, conversion: 9%, enantiomeric excess: 99% | Penicillium chrysogenum | (2R)-2-amino-4-methylpentane + pyruvate | - |
? | |
| 4-methylpentan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus fischeri | (2R)-2-amino-4-methylpentane + pyruvate | - |
? | |
| 4-methylpentan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus fumigatus | (2R)-2-amino-4-methylpentane + pyruvate | - |
? | |
| 4-phenylbutan-2-one + D-alanine | asymmetric synthesis, conversion: 1% | Penicillium chrysogenum | (2R)-2-amino-4-phenylbutane + pyruvate | - |
? | |
| 4-phenylbutan-2-one + D-alanine | asymmetric synthesis, conversion: 32%, enantiomeric excess: 99% | Aspergillus terreus | (2R)-2-amino-4-phenylbutane + pyruvate | - |
? | |
| 4-phenylbutan-2-one + D-alanine | asymmetric synthesis, conversion: 89%, enantiomeric excess: 99% | Mycolicibacterium vanbaalenii | (2R)-2-amino-4-phenylbutane + pyruvate | - |
? | |
| 4-phenylbutan-2-one + D-alanine | asymmetric synthesis, conversion: 9%, enantiomeric excess: 99% | Fusarium graminearum | (2R)-2-amino-4-phenylbutane + pyruvate | - |
? | |
| 4-phenylbutan-2-one + D-alanine | asymmetric synthesis, conversion: 92%, enantiomeric excess: 99% | Aspergillus oryzae | (2R)-2-amino-4-phenylbutane + pyruvate | - |
? | |
| 4-phenylbutan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus fischeri | (2R)-2-amino-4-phenylbutane + pyruvate | - |
? | |
| 4-phenylbutan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus fumigatus | (2R)-2-amino-4-phenylbutane + pyruvate | - |
? | |
| heptan-2-one + D-alanine | asymmetric synthesis, conversion: 15%, enantiomeric excess: 99% | Penicillium chrysogenum | (2R)-2-aminoheptane + pyruvate | - |
? | |
| heptan-2-one + D-alanine | asymmetric synthesis, conversion: 43%, enantiomeric excess: 99% | Fusarium graminearum | (2R)-2-aminoheptane + pyruvate | - |
? | |
| heptan-2-one + D-alanine | asymmetric synthesis, conversion: 69%, enantiomeric excess: 99% | Mycolicibacterium vanbaalenii | (2R)-2-aminoheptane + pyruvate | - |
? | |
| heptan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus fischeri | (2R)-2-aminoheptane + pyruvate | - |
? | |
| heptan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus oryzae | (2R)-2-aminoheptane + pyruvate | - |
? | |
| heptan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus terreus | (2R)-2-aminoheptane + pyruvate | - |
? | |
| heptan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus fumigatus | (2R)-2-aminoheptane + pyruvate | - |
? | |
| hexan-2-one + D-alanine | asymmetric synthesis, conversion: 1% | Penicillium chrysogenum | (2R)-2-aminohexane + pyruvate | - |
? | |
| hexan-2-one + D-alanine | asymmetric synthesis, conversion: 14%, enantiomeric excess: 99% | Fusarium graminearum | (2R)-2-aminohexane + pyruvate | - |
? | |
| hexan-2-one + D-alanine | asymmetric synthesis, conversion: 88%, enantiomeric excess: 99% | Mycolicibacterium vanbaalenii | (2R)-2-aminohexane + pyruvate | - |
? | |
| hexan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus fischeri | (2R)-2-aminohexane + pyruvate | - |
? | |
| hexan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus oryzae | (2R)-2-aminohexane + pyruvate | - |
? | |
| hexan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus terreus | (2R)-2-aminohexane + pyruvate | - |
? | |
| hexan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus fumigatus | (2R)-2-aminohexane + pyruvate | - |
? | |
| nonan-2-one + D-alanine | asymmetric synthesis, conversion: 12%, enantiomeric excess: 99% | Penicillium chrysogenum | (2R)-2-aminononane + pyruvate | - |
? | |
| nonan-2-one + D-alanine | asymmetric synthesis, conversion: 23%, enantiomeric excess: 99% | Fusarium graminearum | (2R)-2-aminononane + pyruvate | - |
? | |
| nonan-2-one + D-alanine | asymmetric synthesis, conversion: 65%, enantiomeric excess: 99% | Mycolicibacterium vanbaalenii | (2R)-2-aminononane + pyruvate | - |
? | |
| nonan-2-one + D-alanine | asymmetric synthesis, conversion: 77%, enantiomeric excess: 99% | Aspergillus oryzae | (2R)-2-aminononane + pyruvate | - |
? | |
| nonan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus fischeri | (2R)-2-aminononane + pyruvate | - |
? | |
| nonan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus terreus | (2R)-2-aminononane + pyruvate | - |
? | |
| nonan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus fumigatus | (2R)-2-aminononane + pyruvate | - |
? | |
| pentan-2-one + D-alanine | asymmetric synthesis, conversion: 1% | Penicillium chrysogenum | (2R)-2-aminopentane + pyruvate | - |
? | |
| pentan-2-one + D-alanine | asymmetric synthesis, conversion: 30%, enantiomeric excess: 99% | Fusarium graminearum | (2R)-2-aminopentane + pyruvate | - |
? | |
| pentan-2-one + D-alanine | asymmetric synthesis, conversion: 47%, enantiomeric excess: 99% | Aspergillus terreus | (2R)-2-aminopentane + pyruvate | - |
? | |
| pentan-2-one + D-alanine | asymmetric synthesis, conversion: 66%, enantiomeric excess: 99% | Mycolicibacterium vanbaalenii | (2R)-2-aminopentane + pyruvate | - |
? | |
| pentan-2-one + D-alanine | asymmetric synthesis, conversion: 92%, enantiomeric excess: 99% | Aspergillus oryzae | (2R)-2-aminopentane + pyruvate | - |
? | |
| pentan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus fischeri | (2R)-2-aminopentane + pyruvate | - |
? | |
| pentan-2-one + D-alanine | asymmetric synthesis, conversion: 99%, enantiomeric excess: 99% | Aspergillus fumigatus | (2R)-2-aminopentane + pyruvate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AspFum | - |
Aspergillus fumigatus |
| AspOry | - |
Aspergillus oryzae |
| AspTer | - |
Aspergillus terreus |
| GibZea | - |
Fusarium graminearum |
| MycVan | - |
Mycolicibacterium vanbaalenii |
| NeoFis | - |
Aspergillus fischeri |
| PenChr | - |
Penicillium chrysogenum |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Penicillium chrysogenum |
| 30 | - |
assay at | Aspergillus fischeri |
| 30 | - |
assay at | Aspergillus oryzae |
| 30 | - |
assay at | Aspergillus terreus |
| 30 | - |
assay at | Aspergillus fumigatus |
| 30 | - |
assay at | Fusarium graminearum |
| 30 | - |
assay at | Mycolicibacterium vanbaalenii |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
- |
Fusarium graminearum |
| 7.5 | - |
assay at | Penicillium chrysogenum |
| 7.5 | - |
assay at | Aspergillus fischeri |
| 7.5 | - |
assay at | Aspergillus oryzae |
| 7.5 | - |
assay at | Aspergillus terreus |
| 7.5 | - |
assay at | Aspergillus fumigatus |
| 7.5 | - |
assay at | Mycolicibacterium vanbaalenii |
| 9 | - |
80% activity at pH 9 | Mycolicibacterium vanbaalenii |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8.5 | optimal activity | Mycolicibacterium vanbaalenii |
| 8 | 9 | optimal activity | Aspergillus fischeri |
| 8 | 9 | optimal activity | Aspergillus oryzae |
| 8 | 9 | optimal activity | Aspergillus fumigatus |
| 8.5 | 9 | optimal activity | Penicillium chrysogenum |
| 8.5 | 9 | optimal activity | Aspergillus terreus |
| 8.5 | 9 | loses 30 to 70% activity at pH 8.5 and pH 9, respectively | Fusarium graminearum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Penicillium chrysogenum | |
| pyridoxal 5'-phosphate | - |
Aspergillus fischeri | |
| pyridoxal 5'-phosphate | - |
Aspergillus oryzae | |
| pyridoxal 5'-phosphate | - |
Aspergillus terreus | |
| pyridoxal 5'-phosphate | - |
Aspergillus fumigatus | |
| pyridoxal 5'-phosphate | - |
Fusarium graminearum | |
| pyridoxal 5'-phosphate | - |
Mycolicibacterium vanbaalenii | |
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