Literature summary for 2.6.1.18 extracted from

Fuchs, C.; Simon, R.; Riethorst, W.; Zepeck, F.; Kroutil, W.
Synthesis of (R)- or (S)-valinol using omega-transaminases in aqueous and organic media (2014), Bioorg. Med. Chem., 22, 5558-5562.

Search for more literature for 2.6.1.18

Application

Application	Comment	Organism
synthesis	optically pure valinol (ee >99%) is prepared employing different omega-transaminases from the corresponding prochiral hydroxy ketone. By the choice of the enzyme the (R)- as well as the (S)-enantiomer are accessible	Arabidopsis thaliana
synthesis	optically pure valinol (ee >99%) is prepared employing different omega-transaminases from the corresponding prochiral hydroxy ketone. By the choice of the enzyme the (R)- as well as the (S)-enantiomer are accessible	Priestia megaterium
synthesis	optically pure valinol (ee >99%) is prepared employing different omega-transaminases from the corresponding prochiral hydroxy ketone. By the choice of the enzyme the (R)- as well as the (S)-enantiomer are accessible	Fusarium graminearum

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	-	-	-
Fusarium graminearum	-	-	-
Priestia megaterium	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-hydroxy-3-methylbutan-2-one + L-alanine	-	Priestia megaterium	(2R)-2-amino-3-methylbutan-1-ol + pyruvate	aqueous medium, 99% conversion, 99% ee	?
1-hydroxy-3-methylbutan-2-one + L-alanine	-	Arabidopsis thaliana	(2S)-2-amino-3-methylbutan-1-ol + pyruvate	aqueous medium, 99% conversion, 99% ee	?
1-hydroxy-3-methylbutan-2-one + L-alanine	-	Fusarium graminearum	(2S)-2-amino-3-methylbutan-1-ol + pyruvate	aqueous medium, 99% conversion, 99% ee	?

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Release 2023.1 (January 2023)