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Literature summary for 2.6.1.13 extracted from

  • Wang, G.; Shang, L.; Burgett, A.W.; Harran, P.G.; Wang, X.
    Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division (2007), Proc. Natl. Acad. Sci. USA, 104, 2068-2073.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.6.1.13

Application

Application Comment Organism
medicine role in mitotic cell division and target for chemotherapeutic drug development Homo sapiens
medicine role in mitotic cell division and target for chemotherapeutic drug development Xenopus sp.

Inhibitors

Inhibitors Comment Organism Structure
4-Aminohex-5-ynoic acid dose-dependent inhibitor Homo sapiens
4-Aminohex-5-ynoic acid dose-dependent inhibitor Xenopus sp.
additional information no inhibition by diazonamide A and syndistatin Homo sapiens
additional information no inhibition by diazonamide A and syndistatin Xenopus sp.

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-
mitochondrion
-
 Xenopus sp. 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Xenopus sp.
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Hitrap Q anion exchange chromatography Homo sapiens
Hitrap Q anion exchange chromatography Xenopus sp.

Source Tissue

Source Tissue Comment Organism Textmining
egg
-
 Xenopus sp.
-
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine + 2-oxoglutarate
-
 Homo sapiens DELTA1-pyrroline-5-carboxylate + L-glutamate
-
 ?
L-ornithine + 2-oxoglutarate
-
 Xenopus sp. DELTA1-pyrroline-5-carboxylate + L-glutamate
-
 ?

Synonyms

Synonyms Comment Organism
OAT
-
 Homo sapiens
OAT
-
 Xenopus sp.
ornithine delta-amino transferase
-
 Homo sapiens
ornithine delta-amino transferase
-
 Xenopus sp.

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Homo sapiens
pyridoxal 5'-phosphate
-
 Xenopus sp.