Crystallization (Comment) | Organism |
---|---|
- |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-aminooxyacetic acid | - |
Homo sapiens | |
2-aminooxyacetic acid | almost complete inhibition at 0.2 mM | Rattus norvegicus | |
5-Fluoromethylornithine | competitive | Homo sapiens | |
5-Fluoromethylornithine | - |
Rattus norvegicus | |
L-canaline | irreversible | Homo sapiens | |
L-canaline | - |
Rattus norvegicus | |
additional information | overview: inhibitors | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial matrix | - |
Homo sapiens | 5759 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
45000 | - |
- |
Rattus norvegicus |
45000 | - |
mature protein | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine + 2-oxoglutarate | Rattus norvegicus | - |
DELTA1-pyrroline-5-carboxylate + L-glutamate | - |
? | |
L-ornithine + 2-oxoglutarate | Homo sapiens | urea cycle | DELTA1-pyrroline-5-carboxylate + L-glutamate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
hereditary enzyme deficiency | - |
Rattus norvegicus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
L-ornithine + a 2-oxo carboxylate = L-glutamate 5-semialdehyde + an L-amino acid | mechanism | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | - |
Homo sapiens | - |
kidney | - |
Rattus norvegicus | - |
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
retina | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine + 2-oxoglutarate | - |
Rattus norvegicus | DELTA1-pyrroline-5-carboxylate + L-glutamate | - |
? | |
L-ornithine + 2-oxoglutarate | - |
Homo sapiens | DELTA1-pyrroline-5-carboxylate + L-glutamate | glutamate-gamma semialdehyde spontaneously cyclizes to form DELTA1-pyrroline-5-carboxylate | ? | |
L-ornithine + 2-oxoglutarate | - |
Rattus norvegicus | DELTA1-pyrroline-5-carboxylate + L-glutamate | glutamate-gamma semialdehyde spontaneously cyclizes to form DELTA1-pyrroline-5-carboxylate | ? | |
L-ornithine + 2-oxoglutarate | urea cycle | Homo sapiens | DELTA1-pyrroline-5-carboxylate + L-glutamate | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Homo sapiens | |
pyridoxal 5'-phosphate | - |
Rattus norvegicus |