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Literature summary for 2.6.1.11 extracted from

  • Friedrich, B.; Friedrich, C.G.; Magasanik, B.
    Catabolic N2-acetylornithine 5-aminotransferase of Klebsiella aerogenes: control of synthesis by induction, catabolite repression, and activation by glutamine synthetase (1978), J. Bacteriol., 133, 686-691.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.6.1.11

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.7
-
 2-oxoglutarate cosubstrate acetylornithine Klebsiella aerogenes
1.1
-
 N2-Acetyl-L-ornithine
-
 Klebsiella aerogenes

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
27000
-
 2 * 27000, SDS-PAGE Klebsiella aerogenes
59000
-
 arginine-inducible catabolic enzyme, gel filtration Klebsiella aerogenes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N2-acetyl-L-ornithine + 2-oxoglutarate Klebsiella aerogenes arginine degradation, arginine-inducible catabolic enzyme N-acetyl-L-glutamate-gamma-semialdehyde + L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Klebsiella aerogenes
-
 one arginine-inducible form and one arginine-repressible form
-

Purification (Commentary)

Purification (Comment) Organism
arginine-inducible form, partial purification of arginine-repressible form Klebsiella aerogenes

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
34.6
-
-
 Klebsiella aerogenes

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information not: putrescine Klebsiella aerogenes ?
-
 ?
additional information purified enzyme also has activity of EC 2.6.1.13 Klebsiella aerogenes ?
-
 ?
additional information 4-aminobutyrate Klebsiella aerogenes ?
-
 ?
N2-acetyl-L-ornithine + 2-oxoglutarate arginine degradation, arginine-inducible catabolic enzyme Klebsiella aerogenes N-acetyl-L-glutamate-gamma-semialdehyde + L-glutamate
-
 ?
N2-acetyl-L-ornithine + 2-oxohexanedioic acid i.e. 2-ketoadipate Klebsiella aerogenes N-acetyl-L-glutamate 5-semialdehyde + 2-aminohexanedioic acid
-
 ?
Nalpha-acetyl-L-ornithine + 2-oxoglutarate
-
 Klebsiella aerogenes N-acetyl-L-glutamate 5-semialdehyde + L-glutamate
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 27000, SDS-PAGE Klebsiella aerogenes

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.1
-
 biosynthetic enzyme Klebsiella aerogenes
8.7
-
 catabolic enzyme Klebsiella aerogenes

pH Range

pH Minimum pH Maximum Comment Organism
6.5 10 active over the range, catabolic enzyme Klebsiella aerogenes

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate a pyridoxal phosphate protein Klebsiella aerogenes