Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.6.1.1 extracted from

  • Yang, Y.
    Enhancing doxorubicin efficacy through inhibition of aspartate transaminase in triple-negative breast cancer cells (2016), Biochem. Biophys. Res. Commun., 473, 1295-1300.
    View publication on PubMed

Application

Application Comment Organism
medicine following doxorubicin administration, triple-negative breast cancer cells, which do not express the estrogen receptor, the progesterone receptor, and the human epidermal growth factor receptor, acquire metabolic alteration, causing increased glutamine flux for the synthesis of aspartate which can be converted into oxaloacetate by GOT1. Subsequently, this oxaloacetate is converted into malate and then pyruvate, maintaining the NADP+/NADPH ratio which neutralizes doxorubicin-induced oxidative stress. Repression of GOT1 results in doxorubicin-induced formation of reactive oxygen species, thereby increasing doxorubicin sensitivity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P17174
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BT-549 cell
-
Homo sapiens
-
MDA-MB-231 cell
-
Homo sapiens
-
MDA-MB-436 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
GOT1
-
Homo sapiens