Application | Comment | Organism |
---|---|---|
medicine | following doxorubicin administration, triple-negative breast cancer cells, which do not express the estrogen receptor, the progesterone receptor, and the human epidermal growth factor receptor, acquire metabolic alteration, causing increased glutamine flux for the synthesis of aspartate which can be converted into oxaloacetate by GOT1. Subsequently, this oxaloacetate is converted into malate and then pyruvate, maintaining the NADP+/NADPH ratio which neutralizes doxorubicin-induced oxidative stress. Repression of GOT1 results in doxorubicin-induced formation of reactive oxygen species, thereby increasing doxorubicin sensitivity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P17174 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BT-549 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
MDA-MB-436 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
GOT1 | - |
Homo sapiens |