Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-oxoglutaconate | injection into mice leads to inhibition of the kidney enzyme | Mus musculus | |
2-oxoglutaconate | 2-oxoglutarate protects against inhibition, L-glutamate enhances the inhibitory effect; 30% inhibition at 25°C, pH 7.2, 10 mM, after 2 h; cytosolic and mitochondrial isozymes | Rattus norvegicus | |
2-oxoglutaconate | 2-oxoglutarate protects against inhibition, L-glutamate enhances the inhibitory effect; 30% inhibition at 25°C, pH 7.2, 10 mM, after 2 h; binds the active site of the pyridoxal 5'-phosphate enzyme form, cytosolic isozyme | Sus scrofa | |
2-oxoglutaconic acid dimethyl ester | 15% inhibition at 25°C, pH 7.0, 10 mM, after 2 h; pyridoxal 5'-phosphate enzyme form, cytosolic isozyme | Sus scrofa | |
N-ethylmaleimide | alkylation of cysteine residues | Sus scrofa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | cytosolic isoenzyme | Rattus norvegicus | 5829 | - |
cytosol | cytosolic isoenzyme | Sus scrofa | 5829 | - |
mitochondrion | mitochondrial isoenzyme | Rattus norvegicus | 5739 | - |
mitochondrion | mitochondrial isoenzyme | Sus scrofa | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-aspartate + 2-oxoglutarate | Mus musculus | - |
oxaloacetate + L-glutamate | - |
? | |
L-aspartate + 2-oxoglutarate | Rattus norvegicus | - |
oxaloacetate + L-glutamate | - |
? | |
L-aspartate + 2-oxoglutarate | Sus scrofa | - |
oxaloacetate + L-glutamate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
male Wistar rats | - |
Rattus norvegicus | - |
cytosolic and mitochondrial isozyme | - |
Sus scrofa | - |
purified cytosolic isozyme | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Sus scrofa | - |
kidney | - |
Mus musculus | - |
kidney | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-aspartate + 2-oxoglutarate | - |
Mus musculus | oxaloacetate + L-glutamate | - |
? | |
L-aspartate + 2-oxoglutarate | - |
Rattus norvegicus | oxaloacetate + L-glutamate | - |
? | |
L-aspartate + 2-oxoglutarate | - |
Sus scrofa | oxaloacetate + L-glutamate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AspAT | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | a pyridoxal 5'-phosphate protein | Mus musculus | |
pyridoxal 5'-phosphate | a pyridoxal 5'-phosphate protein | Rattus norvegicus | |
pyridoxal 5'-phosphate | a pyridoxal 5'-phosphate protein | Sus scrofa | |
pyridoxal 5'-phosphate | bound to the active site | Sus scrofa |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
2 | - |
2-oxoglutaconate | cytosolic isozyme, 25°C, pH 7.2 | Sus scrofa |