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Literature summary for 2.5.1.96 extracted from

  • Steiger, S.; Perez-Fons, L.; Cutting, S.M.; Fraser, P.D.; Sandmann, G.
    Annotation and functional assignment of the genes for the C30 carotenoid pathways from the genomes of two bacteria: Bacillus indicus and Bacillus firmus (2015), Microbiology, 161, 194-202.
    View publication on PubMed
Search for more literature for 2.5.1.96

Cloned(Commentary)

Cloned (Comment) Organism
gene crtM, DNA and amino acid sequence determination and analysis, genetic organization, sequence comparisons, phylogenetic tree, functional pathway complementation by recombinant enzyme expression in Escherichia coli Cytobacillus firmus
gene crtM, DNA and amino acid sequence determination and analysis, genetic organization, sequence comparisons, phylogenetic tree, functional pathway complementation by recombinant enzyme expression in Escherichia coli Metabacillus indicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 (2E,6E)-farnesyl diphosphate Cytobacillus firmus
-
 15-cis-4,4'-diapophytoene + 2 diphosphate
-
 ?
2 (2E,6E)-farnesyl diphosphate Metabacillus indicus
-
 15-cis-4,4'-diapophytoene + 2 diphosphate
-
 ?
2 (2E,6E)-farnesyl diphosphate Metabacillus indicus HU36
-
 15-cis-4,4'-diapophytoene + 2 diphosphate
-
 ?
2 (2E,6E)-farnesyl diphosphate Cytobacillus firmus GB1
-
 15-cis-4,4'-diapophytoene + 2 diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Cytobacillus firmus
-
 gene crtM
-
Cytobacillus firmus GB1
-
 gene crtM
-
Metabacillus indicus
-
 gene crtM
-
Metabacillus indicus HU36
-
 gene crtM
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 (2E,6E)-farnesyl diphosphate
-
 Cytobacillus firmus 15-cis-4,4'-diapophytoene + 2 diphosphate
-
 ?
2 (2E,6E)-farnesyl diphosphate
-
 Metabacillus indicus 15-cis-4,4'-diapophytoene + 2 diphosphate
-
 ?
2 (2E,6E)-farnesyl diphosphate
-
 Metabacillus indicus HU36 15-cis-4,4'-diapophytoene + 2 diphosphate
-
 ?
2 (2E,6E)-farnesyl diphosphate
-
 Cytobacillus firmus GB1 15-cis-4,4'-diapophytoene + 2 diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
CrtM
-
 Cytobacillus firmus
CrtM
-
 Metabacillus indicus
diapophytoene synthase
-
 Cytobacillus firmus
diapophytoene synthase
-
 Metabacillus indicus

General Information

General Information Comment Organism
metabolism Bacillus firmus synthesizes C30 carotenoids via farnesyl pyrophosphate, forming apophytoene as the first committed step in the pathway. The products of the pathway is methyl 4'-[(6-O-acyl-glycosyl)oxy]-4,4'-diapolycopen-4-oic acid and 4,4'-diapolycopen-4,4'-dioic acid with putative glycosyl esters Cytobacillus firmus
metabolism Bacillus indicus synthesizes C30 carotenoids via farnesyl pyrophosphate, forming apophytoene as the first committed step in the pathway. The products of the pathway is methyl 4'-[(6-O-acyl-glycosyl)oxy]-4,4'-diapolycopen-4-oic acid and 4,4'-diapolycopen-4,4'-dioic acid with putative glycosyl esters Metabacillus indicus