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Literature summary for 2.5.1.96 extracted from

  • Wieland, B.; Feil, C.; Gloria-Maercker, E.; Thumm, G.; Lechner, M.; Bravo, J.M.; Poralla, K.; Gotz, F.
    Genetic and biochemical analyses of the biosynthesis of the yellow carotenoid 4,4'-diaponeurosporene of Staphylococcus aureus (1994), J. Bacteriol., 176, 7719-7726.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Staphylococcus aureus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30121
-
 x * 30121, calculated Staphylococcus aureus

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus O07854
-
-
Staphylococcus aureus Newman O07854
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 (2E,6E)-farnesyl diphosphate
-
 Staphylococcus aureus cis-4,4'-diapophytoene + 2 diphosphate
-
 ?
2 (2E,6E)-farnesyl diphosphate
-
 Staphylococcus aureus Newman cis-4,4'-diapophytoene + 2 diphosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 30121, calculated Staphylococcus aureus

General Information

General Information Comment Organism
physiological function the biosynthesis of 4,4'-diaponeurosporene starts with the condensation of two molecules of farnesyl diphosphate by dehydrosqualene synthase CrtM, the reaction product of this enzyme is dehydrosqualene and not squalene. Dehydrosqualene, i.e.4,4'-diapophytoene, is successively dehydrogenated by desaturase CrtN to form the yellow main intermediate 4,4'-diaponeurosporene Staphylococcus aureus