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Literature summary for 2.5.1.94 extracted from
- Enzymatic fluorination and biotechnological developments of the fluorinase (2015), Chem. Rev., 115, 634-649.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene salL, the gene is located in the middle of this salinosporamide A cluster | Salinispora tropica |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | gene replacement of gene salL from Salinispora tropica by gene flA, EC 2.5.1.63, encoding fluorinase from Streptomaces cattleya, the recombinant fluorinase is functional in Salinispora tropica | Salinispora tropica |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine + chloride | Salinispora tropica | - |
5'-deoxy-5'-chloroadenosine + L-methionine | - |
r |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Salinispora tropica | - |
a marine organism, gene salL | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | chlorinase does not accept fluoride ion as a substrate | Salinispora tropica | ? | - |
? | |
| S-adenosyl-L-methionine + chloride | - |
Salinispora tropica | 5'-deoxy-5'-chloroadenosine + L-methionine | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| chlorinase | - |
Salinispora tropica |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme is responsible for salinosporamide-A biosynthesis | Salinispora tropica |
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Release 2023.1 (January 2023)
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