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Literature summary for 2.5.1.90 extracted from

  • Lu, Y.P.; Liu, H.G.; Liang, P.H.
    Different reaction mechanisms for cis- and trans-prenyltransferases (2009), Biochem. Biophys. Res. Commun., 379, 351-355.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Escherichia coli
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Reaction

Reaction Comment Organism Reaction ID
(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-octaprenyl diphosphate sequential mechanism Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,6E)-farnesyl diphosphate + 3-bromo-3-butenyl diphosphate isopentenyl diphosphate analogue, showing a significantly reduced activity. Only two 3-bromo-3-butenyl diphosphate condensation reactions occurr in 24 h and the reaction products do not reach C40 and C55. Use results in trapping of farnesol in the reaction from radioloabeled farnesyl diphosphate under basic conditions, consistent with a sequential mechanism Escherichia coli diphosphate + ?
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?
(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate
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Escherichia coli 5 diphosphate + all-trans-octaprenyl diphosphate
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?

Synonyms

Synonyms Comment Organism
OPPs
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Escherichia coli