Literature summary for 2.5.1.90 extracted from

Choi, J.-H.; Ryu, Y.-W.; Park, Y.-C.; Seo, J.-H.
Synergistic effects of chromosomal ispB deletion and dxs overexpression on coenzyme Q10 production in recombinant Escherichia coli expressing Agrobacterium tumefaciens dps gene (2009), J. Biotechnol., 144, 64-69.

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Protein Variants

Protein Variants	Comment	Organism
additional information	for biotechnological production of coenzyme Q10 in recombinant Escherichia coli, three genetic manipulations are performed: heterologous expression of decaprenyl diphosphate synthase (Dps) from Agrobacterium tumefaciens, deletion of endogenous octaprenyl diphosphate synthase (IspB), and overexpression of 1-deoxy-D-xylulose synthase (Dxs). Expression of the dps gene and deletion of the ispB gene in Escherichia coli BL21(DE3)DELTAispB/pAP1 allows production of CoQ10 only. Coexpression of the dxs gene increases the specific content of CoQ10	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P0AD57	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate	-	Escherichia coli	5 diphosphate + all-trans-octaprenyl diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
IspB	-	Escherichia coli

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Release 2023.1 (January 2023)