Application | Comment | Organism |
---|---|---|
additional information | the enzyme is a target for development of antimicrobial drugs | Escherichia coli |
Crystallization (Comment) | Organism |
---|---|
purified recombinant homodimeric N-terminal enzyme domain in complex with riboflavin, 7 mg/ml protein in 70 mM sodium potassium phosphate, pH 7.0, and 100 mM sodium chloride, X-ray diffraction structure determination and analysis at 2.6 A resolution, molecular modeling | Escherichia coli |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
70000 | - |
- |
Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
6,7-dimethyl-8-(1-D-ribityl)lumazine | Escherichia coli | ultimate step in the biosynthesis of riboflavin, i.e. vitamin B2, the precursor of flavin cofactors | riboflavin + 5-amino-6-ribitylamino-2,4-(1H,3H)-pyrimidinedione | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0AFU8 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine | active site structure and catalytic mechanism | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6,7-dimethyl-8-(1-D-ribityl)lumazine | dismutation | Escherichia coli | riboflavin + 5-amino-6-ribitylamino-2,4-(1H,3H)-pyrimidinedione | riboflavin binding site structure | ? | |
6,7-dimethyl-8-(1-D-ribityl)lumazine | ultimate step in the biosynthesis of riboflavin, i.e. vitamin B2, the precursor of flavin cofactors | Escherichia coli | riboflavin + 5-amino-6-ribitylamino-2,4-(1H,3H)-pyrimidinedione | - |
? |
Subunits | Comment | Organism |
---|---|---|
trimer | subunit fold and arrangement, beta-barrel capped by short alpha-helices on each side, overview | Escherichia coli |