Literature summary for 2.5.1.86 extracted from

Grover, S.; Alderwick, L.J.; Mishra, A.K.; Krumbach, K.; Marienhagen, J.; Eggeling, L.; Bhatt, A.; Besra, G.S.
Benzothiazinones mediate killing of Corynebacterineae by blocking decaprenyl phosphate recycling involved in cell wall biosynthesis (2014), J. Biol. Chem., 289, 6177-6187.

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Cloned(Commentary)

Cloned (Comment)	Organism
gene NCgl2203 or uppS2, recombinant overexpression in wild-type Corynebacterium glutamicum eliciting an increase in decaprenyl phosphate synthesis	Corynebacterium glutamicum

Protein Variants

Protein Variants	Comment	Organism
additional information	overexpression of Z-decaprenyl-diphosphate synthase gene NCgl2203 in wild-type Corynebacterium glutamicum increases resistance to benzothiazinone BTZ043	Corynebacterium glutamicum

Inhibitors

Inhibitors	Comment	Organism	Structure
2-(2-methyl-1,3-dioxa-8-azaspiro[4.5]dec-8-yl)-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one	i.e. BTZ043. Benzothiazinones mediate killing of Corynebacterineae by blocking decaprenyl phosphate recycling involved in cell wall biosynthesis. In the presence of benzothiazinones (BTZ), the bacilli accumulate decaprenyl-phosphoribose and fail to recycle decaprenyl phosphate, which results in the depletion of decaprenyl phosphate and ultimately leads to cell death. Overexpression of Z-decaprenyl-diphosphate synthase gene NCgl2203 in wild-type Corynebacterium glutamicum increases resistance to benzothiazinone BTZ043. BTZ043 targets DprE1, which is a FAD-containing oxidoreductase involved in the epimerization of decaprenyl-phosphoribose to decaprenyl-phosphoarabinose	Corynebacterium glutamicum

Organism

Organism	UniProt	Comment	Textmining
Corynebacterium glutamicum	Q8NNC1	gene NCgl2203 or uppS2	-
Corynebacterium glutamicum DSM 20300	Q8NNC1	gene NCgl2203 or uppS2	-

Synonyms

Synonyms	Comment	Organism
Z-decaprenyl-diphosphate synthase	-	Corynebacterium glutamicum

General Information

General Information	Comment	Organism
physiological function	overexpression of Z-decaprenyl-diphosphate synthase gene NCgl2203 in wild-type Corynebacterium glutamicum increases resistance to benzothiazinone BTZ043	Corynebacterium glutamicum

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Release 2023.1 (January 2023)