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Literature summary for 2.5.1.84 extracted from

  • Teclebrhan, H.; Olsson, J.; Swiezewska, E.; Dallner, G.
    Biosynthesis of the side chain of ubiquinone:trans-prenyltransferase in rat liver microsomes (1993), J. Biol. Chem., 268, 23081-23086.
    View publication on PubMed
Search for more literature for 2.5.1.84

Activating Compound

Activating Compound Comment Organism Structure
Digitonin
-
 Rattus norvegicus
Digitonin 0.005%, 29fold activation Rattus norvegicus
taurodeoxycholate 0.005%, 1.3fold activation Rattus norvegicus
Tween-80 0.005%, 1.4fold activation Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1-O-octyl-beta-D-glucopyranoside 0.1%, 44% inhibition Rattus norvegicus
Ca2+ 1 mM (in absence of Mn2+ or Mg2+), complete inhibition Rattus norvegicus
deoxycholate 0.01%, 70% inhibition Rattus norvegicus
SDS 0.005%, 78% inhibition Rattus norvegicus
Triton X-100 0.05%, 53% inhibition Rattus norvegicus
Zn2+ 1 mM (in absence of Mn2+ or Mg2+), complete inhibition Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ no activity in absence of divalent metal ion, activation with 2 mM Mg2+ is 50% of that obtained with Mn2+ Rattus norvegicus
Mn2+ no activity in absence of divalent metal ion, 0.1 mM Mn2+ is required for optimal activity Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
all-trans-farnesyl diphosphate + 6 isopentenyl diphosphate about 10% of the activity with geranyl diphosphate Rattus norvegicus 6 diphosphate + all-trans-nonaprenyl diphosphate
-
 ?
geranyl diphosphate + 7 isopentenyl diphosphate
-
 Rattus norvegicus 7 diphosphate + all-trans-nonaprenyl diphosphate
-
 ?
geranylgeranyl diphosphate + 5 isopentenyl diphosphate about 25% of the activity with geranyl diphosphate Rattus norvegicus 5 diphosphate + all-trans-nonaprenyl diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
ubiquinone:trans-prenyltransferase
-
 Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
-
 Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
7 9.5 pH 7.0: about 60% of maximal activity, pH 9.5: about 60% of maximal activity Rattus norvegicus