Literature summary for 2.5.1.81 extracted from

Tachibana, A.; Yano, Y.; Otani, S.; Nomura, N.; Sako, Y.; Taniguchi, M.
Novel prenyltransferase gene encoding farnesylgeranyl diphosphate synthase from a hyperthermophilic archaeon,Aeropyrum pernix. Molecular evolution with alteration in product specificity (2000), Eur. J. Biochem., 267, 321-328.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli as a glutathione S-transferase fusion protein	Aeropyrum pernix

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate	Aeropyrum pernix	Aeropyrum pernix does not possess geranylgeranyl diphosphate synthase and has only C25-C25 ether lipids, but no C20-containing ether lipids. Aeropyrum pernix farnesylgeranyl diphosphate synthase is important in the biosynthesis of the hydrocarbon moiety of membrane lipids	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Aeropyrum pernix	Q9UWR6	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Aeropyrum pernix

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate	Aeropyrum pernix does not possess geranylgeranyl diphosphate synthase and has only C25-C25 ether lipids, but no C20-containing ether lipids. Aeropyrum pernix farnesylgeranyl diphosphate synthase is important in the biosynthesis of the hydrocarbon moiety of membrane lipids	Aeropyrum pernix	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate	-	?
(2E,6E)-farnesyl diphosphate + 2 isopentenyl diphosphate	farnesyl diphosphate is the allylic substrate with the highest activity	Aeropyrum pernix	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 2 diphosphate	-	?
dimethylallyl diphosphate + 4 isopentenyl diphosphate	dimethylallyl diphosphate shows 28% of the activity with farnesyl diphosphate	Aeropyrum pernix	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 4 diphosphate	large amounts of intermediates are formed: geranyl diphosphate, farnesyl diphosphate, geranylgeranyl diphosphate	?
geranyl diphosphate + 3 isopentenyl diphosphate	geranyl diphosphate shows 72% of the activity with farnesyl diphosphate	Aeropyrum pernix	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + 3 diphosphate	-	?
geranylgeranyl diphosphate + isopentenyl diphosphate	geranylgeranyl diphosphate shows 65% of the activity with farnesyl diphosphate	Aeropyrum pernix	(2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
C25 farnesylgeranyl diphosphate synthase	-	-
farnesylgeranyl diphosphate synthase	-	-
FGPP synthase	-	Aeropyrum pernix
Fgs	-	Aeropyrum pernix

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	assay at	Aeropyrum pernix

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Release 2023.1 (January 2023)