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Literature summary for 2.5.1.78 extracted from

  • Tuan, P.; Zhao, S.; Kim, J.; Kim, Y.; Yang, J.; Li, C.; Kim, S.; Arasu, M.; Al-Dhabi, N.; Park, S.
    Riboflavin accumulation and molecular characterization of cDNAs encoding bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase, lumazine synthase, and riboflavin synthase in different organs of Lycium chinense plant (2014), Molecules, 19, 17141-17153.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene LcLS1, DNA and amino acid sequence determination and analysis, sequence comparisons, quantitative real-time PCR expression analysis Lycium chinense
gene LcLS2, DNA and amino acid sequence determination and analysis, sequence comparisons, quantitative real-time PCR expression analysis Lycium chinense

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25070
-
-
 Lycium chinense
25410
-
-
 Lycium chinense

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil Lycium chinense
-
 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H2O + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Lycium chinense W0FEU6 cv. Cheongmyeong, gene LcLS2
-
Lycium chinense W0FJR2 cv. Cheongmyeong, gene LcLS1
-

Source Tissue

Source Tissue Comment Organism Textmining
flower
-
 Lycium chinense
-
fruit green fruits, and red fruits Lycium chinense
-
leaf
-
 Lycium chinense
-
additional information the enzyme is constitutively expressed in all organs examined with the highest expression levels in leaves, lower expression in roots,, stems, and flowers, very low in green fruits Lycium chinense
-
additional information the isozyme LcLS2 is constitutively expressed in all organs examined with the highest expression levels in red fruits, low expression levels in green fruits and roots Lycium chinense
-
root
-
 Lycium chinense
-
stem
-
 Lycium chinense
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6-(D-ribitylamino)uracil
-
 Lycium chinense 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H2O + phosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 25070, LcLS1, sequence calculation Lycium chinense
? x * 25410, LcLS2, sequence calculation Lycium chinense

Synonyms

Synonyms Comment Organism
LcLS1
-
 Lycium chinense
LcLS2
-
 Lycium chinense
lumazine synthase
-
 Lycium chinense

General Information

General Information Comment Organism
metabolism lumazine synthase is involved in the riboflavin biosynthetic pathway and catalyzes the condensation of 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione with 3,4-dihydroxy-2-butanone-4-phosphate, which is obtained from ribulose 5-phosphate by 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBPS), yielding 6,7-dimethyl-8-ribityllumazine. Proposd riboflavin biosynthetic pathway in plants, overview Lycium chinense
additional information the enzyme carries an N-terminal extension typical for plant riboflavin biosynthetic proteins Lycium chinense