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Literature summary for 2.5.1.78 extracted from

  • Mejias, M.P.; Cabrera, G.; Fernandez-Brando, R.J.; Baschkier, A.; Ghersi, G.; Abrey-Recalde, M.J.; Miliwebsky, E.; Meiss, R.; Goldbaum, F.; Zylberman, V.; Rivas, M.; Palermo, M.S.
    Protection of mice against Shiga toxin 2 (Stx2)-associated damage by maternal immunization with a Brucella lumazine synthase-Stx2 B subunit chimera (2014), Infect. Immun., 82, 1491-1499.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
additional information protection of mice against Shiga toxin 2 (Stx2)-associated damage by maternal immunization with a Brucella lumazine synthase-Stx2 B subunit chimera. The enzyme can be useful in vaccine development against enterohemorrhagic Shiga toxin (Stx)-producing Escherichia coli (EHEC), which causes a prodromal hemorrhagic enteritis, remaining the most common etiology of the typical or epidemic form of hemolytic-uremic syndrome. The EHEC challenge contributes to sustain a specific and protective immune response against Stx2 Brucella sp.

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of a His-tagged fusion protein BLS-Stx2B formed by the enzyme and the Shiga toxin B subunit Brucella sp.

Organism

Organism UniProt Comment Textmining
Brucella sp.
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged fusion protein BLS-Stx2B by nickel affinity chromatography Brucella sp.

Synonyms

Synonyms Comment Organism
BLS
-
 Brucella sp.
lumazine synthase
-
 Brucella sp.

General Information

General Information Comment Organism
physiological function protection of mice against Shiga toxin 2 (Stx2)-associated damage by maternal immunization with a Brucella lumazine synthase-Stx2 B subunit chimera.Maternal immunization with BLSStx2B protein antigen as a possible approach for transferring anti-Stx2 protection to the offspring Brucella sp.